Results 81 to 90 of about 162,137 (289)

Levosimendan for the prevention of acute organ dysfunction in sepsis [PDF]

, 2016
BACKGROUND Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis. METHODS We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the ...
Al-Beidh, F, Ashby, D, Best-Lane, J, Brealey, D, Breen, A, Cross, M, Gordon, AC, Liu, KD, Mason, AJ, McAuley, DF, McNamee, JJ, Nutt, CL, Orme, RML, Perkins, GD, Reschreiter, H, Santhakumaran, S, Singer, M   +16 more
core   +2 more sources

Comparison of Isoflurane and Sevoflurane for Controlled Hypotension in Endoscopic Sinus Surgeries and Tympanomastoidectomy

پزشکی بالینی ابن سینا, 2014
Introduction & Objective: Even a little bleeding can adversely affect the surgeon's ability to visualize the region to be operated in ENT operations.
Bijan Yazdi, Esmael Moshiri, Hesamoddin Modir   +2 more
doaj  

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders [PDF]

, 2019
Objective To systematically evaluate the efficacy of treatments for tics and the risks associated with their use. Methods This project followed the methodologies outlined in the 2011 edition of the American Academy of Neurology\u27s guideline development
Cavanna, Andrea E, Holler-Managan, Yolanda, Jankovic, Joseph, Jarvie, Elizabeth, Martino, Davide, Müller-Vahl, Kirsten, Okun, Michael S, Oskoui, Maryam, Piacentini, John, Pringsheim, Tamara, Robinson, Michael, Roessner, Veit, Woods, Douglas W   +12 more
core   +2 more sources

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

, 2016
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial ...
Besecker, Emily Swartz, Cooper, Timothy K., Deiter, Gina M., Holmes, Gregory Michael, Pironi, Nicole   +4 more
core   +1 more source

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice [PDF]

, 2015
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC.
Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Cauwels, Anje, De Cauwer, Lode, Decaluwé, Kelly, Delanghe, Joris, Geschka, Sandra, Hochepied, Tino, Karas, Richard H, Rogge, Elke, Sips, Patrick, Stasch, Johannes-Peter, Tainsh, Robert E, Thoonen, Robrecht, Van de Voorde, Johan, Voet, Sofie, Vuylsteke, Marnik   +17 more
core   +1 more source

ADRENORECEPTORS BLOCKING: RECENT DATA ON URAPIDIL USAGE

Российский кардиологический журнал, 2015
The article is focused on recent (last two years) data from the trials of alphaadrenoblocker urapidil as a drug of choice for severe refractory hypertension, for controlled hypotension, and for outpatient care as part of combination therapy.
O. Yu. Shaydyuk, E. O. Taratukhin
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The Effectiveness of Intravenous Magnesium Sulfate for Deliberate Hypotension in Rhinoplasty

Archives of Anesthesia and Critical Care, 2015
Background: Deliberate hypotension is a strategy that reduces intraoperative bleeding and increases the speed of surgery in otolaryngology procedures. Magnesium (Mg) sulfate is a vasodilator agent that reduces intraoperative hypnotic requirements and in ...
Seyed Mohammad Mireskandari, Kasra Karvandian, Afshin Jafarzadeh, Jalil Makarem, Shahram Samadi, Asghar Hajipour, Negar Eftekhar, Sanaz Shabani, Mohammad Fatehi, Jayran Zebardast   +9 more
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