Results 61 to 70 of about 2,261,928 (284)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Comparison of Hemodynamic Response following Spinal Anesthesia between Controlled Hypertensive and Normotensive Patients Undergoing Surgery below the Umbilicus: An Observational Prospective Cohort Study

Anesthesiology Research and Practice, 2021
Background. Hypotension and bradycardia are the most common complications associated with spinal anesthesia and more common in patients with a history of hypertension. Regular use of antihypertensive medications can prevent these complications.
Leake Gebrargs, Bereket Gebremeskel, Bacha Aberra, Assefa Hika, Yusuf Yimer, Misrak Weldeyohannes, Suleiman Jemal, Degena Behrey, Abere Tilahun   +8 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

PROPRANOLOL DURING CONTROLLED HYPOTENSION

British Journal of Anaesthesia, 1966
SUMMARY The negative chronotrophic effect of propranolol was utilized to treat and prevent tachycardia due to ganglionic blockade in order to determine whether this would enable better control of hypotension. It was concluded that the results justified use of the drug.
J, Hellewell, M W, Potts
openaire   +2 more sources

Adenosine and dialysis hypotension [PDF]

, 2006
In this issue, Imai et al. report the results of a double-blind placebo-controlled study on the effect of an adenosine A1 receptor antagonist, FK352, on the incidence of dialysis hypotension in hypotension-prone patients.
Franssen, CMF, Franssen, CMF; id_orcid, Franssen, C.F.M.   +2 more
core   +1 more source

Arthroscopic Allogeneic Bone Strip Grafting for Recurrent Shoulder Dislocation With Critical Glenoid Bone Loss: A Free Graft Suspension Fixation Technique

Arthroscopy Techniques, EarlyView.
Abstract In patients with recurrent anterior shoulder dislocation and glenoid bone loss between 10% and 20%, isolated Bankart repair remains associated with a certain rate of postoperative redislocation. The optimal management for this patient subset is controversial. We describe an all‐arthroscopic technique using allogeneic bone strips for free graft
Yingbin Wu, Jiang Guo, Weitong Liu, Changbing Wang, Chuying Fu, Lilian Zhao   +5 more
wiley   +1 more source

Magnesium Sulfate Versus Dexmedetomidine in Controlled Hypotension During Spine Surgeries

SVU - International Journal of Medical Sciences
Background: Recent years have seen an unusually large number of patients undergoing posterior spine operations. Studies have recorded blood loss between 1 and 3 liters for posterior spine procedures.
Abady A. Abdellah , Mostafa Ashraf , Salah M. Asida , Mohammed A. Soliman   +3 more
doaj   +1 more source

Analysis of integrated clinical safety data of tadalafil in patients receiving concomitant antihypertensive medications

The Journal of Clinical Hypertension, 2022
This pooled safety analysis assessed the incidence of hypotension‐related treatment‐emergent adverse events (TEAEs) and major adverse cardiovascular events (MACEs) in patients with concomitant use of tadalafil and antihypertensive medications.
Robert A. Kloner, John B. Kostis, Thomas P. McGraw, Chunfu Qiu, Alankar Gupta   +4 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source