Results 91 to 100 of about 1,258,142 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Applying Conversation Analysis to Real-world Concerns

open access: yesStudies in Applied Linguistics & TESOL, 2012
A few weeks ago, I sat in the audience of an atypical professional panel at an uplifting conference. The panel and audience members, all enthusiastic alumni and students of my alma mater’s English Department, were discussing the career paths they had (or
Catherine Box
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

Den etnometodologiske konversationsanalyse som kulturanalytisk metode

open access: yesHermes, 1998
This article will focus on the ethnomethodological conversation analysis (CA) as a method for analysing cultural phenomena in conversation. It will present some of CA’s basic assumptions about the social character of situated interaction and the use of ...
Susanne Kjærbeck
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Vestluskaaslase algatatud parandused telesarja „Õnne 13” telefonikõnedes

open access: yesKeel ja Kirjandus
Other-initiated repair in the phone calls of the TV series Õnne 13 This paper analyzes phone calls from the Estonian television series Õnne 13 (“Happiness Street 13”) using the methodological framework of conversation analysis. The dataset consists of
Andriela Rääbis
doaj   +1 more source

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