Results 111 to 120 of about 175,823 (293)
Issues in Action Formation: Requests and the Problem with x
Open Linguistics, 2017 In previous interactional studies of formats for utterances doing requests, attention has been given to the initial verb (such as can/could or wonder) and possibly the subject (especially I vs you).
Fox Barbara A., Heinemann Trine
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IPCC Fifth Assessment Report - Conversation commentary
, 2014 With the release of the IPCC\u27s Climate change 2014: impacts, adaptation and vulnerability this week, many Australian academics have contributed to the debate at The Conversation ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2013 A recent systematic review of conversation training for communication partners of people with aphasia has shown that it is effective, and improves participation in conversation for people with chronic aphasia.
Best, W +5 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Roundtable: An Abstract Model of Conversation Dynamics [PDF]
Is it possible to abstract a formal mechanism originating schisms and governing the size evolution of social conversations? In this work we propose a constructive solution to this problem: an abstract model of a generic N-party turn-taking conversation ...
Massimo Mastrangeli +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
What are we doing when we analyse conversation?
, 2008 Here I offer a reminder of some of the phenomenological and ethnomethodological roots of conversation analysis (CA) in the form of a set of 'field propositions'. Over the years, CA has certainly 'branched out' from those roots.
McHoul, A.
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