Results 101 to 110 of about 23,464,740 (278)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
"Honourable Bigotry"? Relevance theory, conversation analysis and radio talk-backs
, 2006 Relevance Theory (RT) and Conversation Analysis (CA), two disciplines with a shared interest in the pragmatics of conversation, have interacted very little.
Pattemore, Stephen
core
, 2018 From 1956, when he first published, to his passing on 20 February 2018, the teaching and publications of this Professor Emeritus had a major impact on several generations of geographers and cartographers.
Cybergeo Conversation
core +1 more source
How funny it is when everybody gets going! A case of co-construction of humor in conversation
Círculo de Lingüística Aplicada a la Comunicación, 2023 Humor is built and co-constructed by the participants in conversation, by means of terms and / or attitudes. The paper shows the effects of humor and its co-construction on the interaction itself and on the relationship of the participants to each other.
Beatriz Priego-Valverde
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Komunikowanie emocji w nocnych rozmowach radiowych w świetle paradygmatu analizy konwersacyjnej
Forum Lingwistyczne, 2017 Communicating Emotions in Radio Night Time Talk Shows in the Paradigm of Conversational Analysis Grażyna Stachyra raises the question of night-time radio talk shows, where partners in conversation express their emotions.
Grażyna Stachyra
doaj
Ethnomethodological conversation analysis and the study of assemblages. [PDF]
Front Sociol, 2023 Raudaskoski P.
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source