Results 121 to 130 of about 175,823 (293)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
"Honourable Bigotry"? Relevance theory, conversation analysis and radio talk-backs
, 2006 Relevance Theory (RT) and Conversation Analysis (CA), two disciplines with a shared interest in the pragmatics of conversation, have interacted very little.
Pattemore, Stephen
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, 2010 Kopp S. Social resonance and embodied coordination in face-to-face conversation with artificial interlocutors. Speech Communication. 2010;52(6):587-597.Human natural face-to-face communication is characterized by inter-personal coordination.
Kopp, Stefan ; https://orcid.org/
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
In Conversation with Jonah Conversation Analysis, Literary Criticism and the Book of Jonah
The author analyses the various conversations that occur between the characters in the Jonah narrative and the 'conversation' that occurs between the text and its readers. The study opens with an introduction to the field of conversation analysis, with a
Person, Jr Raymond F. +1 more
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A conversation about healthy eating /
What constitutes a healthy diet? Mainstream media and advertisers would like you to think that the answer to this question is complicated and controversial. But science, fortunately, tells us otherwise. A Conversation about Healthy Eating brings together
Lesica, Nicholas A.,author.
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source