Results 121 to 130 of about 1,269,131 (329)

Rhetorical Strategies in flouting Grice’s Maxims as Found in “Pygmalion”. [PDF]

open access: yes, 2013
Communication is an separable part of human life because people need to express their ideas, feeling ,and thought to one another. Ideally in a communication, the speaker should fulfill the requirements of the message being informative, clear, and ...
Hartanto, Yenny
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Analisis Percakapan dalam Acara “Talk Show Kick Andy dengan Pengarang Novel Negeri Lima Menara” [PDF]

open access: yes, 2018
            The conversation analysis contained in the Kick Andy Talk Show video contains four subjects, including conversation topics, conversation structure, conversation conversation, and ...
anisah, Z. (zulfatun)
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Komunikowanie emocji w nocnych rozmowach radiowych w świetle paradygmatu analizy konwersacyjnej

open access: yesForum Lingwistyczne, 2017
Communicating Emotions in Radio Night Time Talk Shows in the Paradigm of Conversational Analysis Grażyna Stachyra raises the question of night-time radio talk shows, where partners in conversation express their emotions.
Grażyna Stachyra
doaj  

Characterizing Pedophile Conversations on the Internet using Online Grooming [PDF]

open access: yes, 2012
Cyber-crime targeting children such as online pedophile activity are a major and a growing concern to society. A deep understanding of predatory chat conversations on the Internet has implications in designing effective solutions to automatically ...
Gupta, Aditi   +2 more
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

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