Results 91 to 100 of about 1,269,131 (329)

Conversational strategies in children’s talk

open access: yesTaikomoji kalbotyra, 2019
The aim of this article is to investigate linguistic and non-linguistic conversational strategies and their realisations, employed by five year olds in peer interactions. 5 hours and 49 minutes of recorded children’s talk were used for the analysis.
Inga Daraškienė, Inga Hilbig
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Strategic conversation

open access: yesSemantics and Pragmatics, 2013
Models of conversation that rely on a strong notion of cooperation don’t apply to strategic conversation — that is, to conversation where the agents’ motives don’t align, such as courtroom cross examination and political debate.
Nicholas Asher, Alex Lascarides
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

What Can Talk Tell Us About Design? Considering Practice Through Symbolic Interactionism and Conversation Analysis [PDF]

open access: yes, 2009
How can scholars conduct rigorous research into the social activities that help constitute design practice? This paper considers this question through exploring how the interactive aspects of design may be fruitfully examined from the perspective of ...
Oak, Arlene
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

L2 vocabulary development through conversation: A conversation analysis [PDF]

open access: yes, 2004
Through the framework of Conversation Analysis (CA), this study examines conversational interactions and L2 vocabulary development through conversations between conversation partners and L2 learners in one English language teaching institution.
Jung, Kyungran
core  

A Virtual Conversational Agent for Teens with Autism: Experimental Results and Design Lessons

open access: yes, 2020
We present the design of an online social skills development interface for teenagers with autism spectrum disorder (ASD). The interface is intended to enable private conversation practice anywhere, anytime using a web-browser.
Ali M. R.   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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