Results 91 to 100 of about 22,410,299 (279)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Simulation-Based Learning in Training Contexts [PDF]
Educaţia 21This article examines how professionals preparing to become trainers for Școala de Valori/The School of Values association engage in simulation-based learning.
Silvia Bogdan, Natalia-Maria Durușa
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Semantics and Pragmatics, 2013 Models of conversation that rely on a strong notion of cooperation don’t apply to strategic conversation — that is, to conversation where the agents’ motives don’t align, such as courtroom cross examination and political debate.
Nicholas Asher, Alex Lascarides
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Conversational strategies in children’s talk
Taikomoji kalbotyra, 2019 The aim of this article is to investigate linguistic and non-linguistic conversational strategies and their realisations, employed by five year olds in peer interactions. 5 hours and 49 minutes of recorded children’s talk were used for the analysis.
Inga Daraškienė, Inga Hilbig
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Le métro parisien en période pandémique : le privilège de l'immobilité
, 2021 La pandémie du Covid-19 a largement impacté nos mobilités quotidiennes depuis mars 2020. Les confinements successifs, les injonctions au télétravail, les changements de programmes d'activités Conversation proposée par : Olivier Finance Université de ...
Cybergeo Conversation
core
"So let's talk. Let's chat. Let's start a dialogue" : an analysis of the conversation metaphor employed in Clinton's and Obama's YouTube campaign clips [PDF]
, 2008 This paper examines how two American presidential candidates, Barack Obama and Hillary Clinton, make use of a video exchange is conversation metaphor on YouTube, a chann^el of communication that allows the exchange of video clips on the Internet.
Duman, Steve, Locher, Miriam A.
core +2 more sources