Results 71 to 80 of about 23,464,740 (278)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Aspects of aspects: On Harvey Sacks’s “Missing” book, Aspects of the sequential organization of conversation (1970) [PDF]
, 2005 Conversation analysis (CA) is now what Kuhn once called a normal science. It has a discernible body of concepts, methods, and recognizable objects of analysis.
McHoul, A.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
How is conversation analysis used in social work research?
, 2020 In this talk we give an overview of the development of conversation analytic research of social work over the last three decades – from scattered studies in the 1990s to the forming of a viable subfield that can inform professional practice. We map which
Jørgensen, Sabine +4 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
What are we doing when we analyse conversation? [PDF]
, 2008 Here I offer a reminder of some of the phenomenological and ethnomethodological roots of conversation analysis (CA) in the form of a set of 'field propositions'. Over the years, CA has certainly 'branched out' from those roots.
McHoul, A.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
KOREKSI TUTURAN OLEH SBY (STUDI KASUS WAWANCARA KHUSUS “SAATNYA SBY BICARA” DI METRO TV)
Lingua Didaktika: Jurnal Bahasa dan Pembelajaran Bahasa, 2010 This research aims at describing the reasons, mechanism and forms of self-repair as well as describing the relationship between the employment of self-repair and SBY as the speaker.
Susana Widyastuti
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source