Results 81 to 90 of about 1,258,142 (306)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
What Can Talk Tell Us About Design? Considering Practice Through Symbolic Interactionism and Conversation Analysis [PDF]
, 2009 How can scholars conduct rigorous research into the social activities that help constitute design practice? This paper considers this question through exploring how the interactive aspects of design may be fruitfully examined from the perspective of ...
Oak, Arlene
core
Dynamic Role Authorization in Multiparty Conversations [PDF]
, 2014 Protocol specifications often identify the roles involved in communications. In multiparty protocols that involve task delegation it is often useful to consider settings in which different sites may act on behalf of a single role.
Ghilezan, Silvia +4 more
core +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Conversational strategies in children’s talk
Taikomoji kalbotyra, 2019 The aim of this article is to investigate linguistic and non-linguistic conversational strategies and their realisations, employed by five year olds in peer interactions. 5 hours and 49 minutes of recorded children’s talk were used for the analysis.
Inga Daraškienė, Inga Hilbig
doaj +1 more source
A Generative Model of Group Conversation
, 2017 Conversations with non-player characters (NPCs) in games are typically confined to dialogue between a human player and a virtual agent, where the conversation is initiated and controlled by the player.
Martens, Chris, Morrison, Hannah
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Characterizing Pedophile Conversations on the Internet using Online Grooming [PDF]
, 2012 Cyber-crime targeting children such as online pedophile activity are a major and a growing concern to society. A deep understanding of predatory chat conversations on the Internet has implications in designing effective solutions to automatically ...
Gupta, Aditi +2 more
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source