Results 91 to 100 of about 105,542 (378)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Faktor Risiko Bangkitan Kejang Demam pada Anak [PDF]

, 2010
Latar belakang: Kejang demam dapat mengakibatkan gangguan tingkah laku, penurunan nilai akademik dan sangat mengkhawatirkan orang tua anak. Bila faktor risiko diketahui lebih awal dapat dilakukan pencegahan sedini mungkin akan terjadinya bangkitan kejang
Fuadi, Fuadi
core  

Notes from underground: Lisbon after the earthquake [PDF]

, 2008
The Lisbon earthquake of 1 November 1755 occupies a canonical place in eighteenth-century studies, yet surprisingly little attention has been paid to what the rebuilding of the city meant, both culturally and materially.
Hamblyn, Richard
core   +1 more source

Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

Neurologia medico-chirurgica, 2010
The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH)
Y. Enomoto, S. Yoshimura, Kiyofumi Yamada, T. Iwama   +3 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Assessment of Blood pH and pCO2 as Predictors of Febrile Seizures in Paediatric Patients: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Febrile seizures commonly occur in the age group of six months to five years. Hypocarbia and alkalosis are known to enhance neuronal excitability and promote epileptiform activity.
Suhit Banerjee, Tapan Kumar Biswas, Gobinda Mondal, Banasree Roy, Anish Chatterjee   +4 more
doaj   +1 more source

Serum Neurofilament Levels in Children With Febrile Seizures and in Controls

Frontiers in Neuroscience, 2020
ObjectiveNeuroaxonal damage is reflected by serum neurofilament light chain (sNfL) values in a variety of acute and degenerative diseases of the brain. The aim of this study was to investigate the impact of febrile and epileptic seizures on sNfL, serum ...
Katrina S. Evers, Melanie Hügli, Sotirios Fouzas, Severin Kasser, Christian Pohl, Christian Pohl, Benjamin Stoecklin, Luca Bernasconi, Jens Kuhle, Sven Wellmann, Sven Wellmann   +10 more
doaj   +1 more source

Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. [PDF]

, 2015
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Abagyan, Ruben, Ali, Thibault B, Chen, Winston Yuchen, Reilly, Brian M, Schleret, Thomas R   +4 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source