Results 111 to 120 of about 31,866 (253)

Experimental Study on Inhibition of the ep-Mouse Convulsion Part 4 Influence of Adrenal Glands and Genital Glands on the ep-Mouse Convulsion [PDF]

, 1962
An attempt was made to study the influence of unilateral or bilateral adrenectomy of the ep-mouse, exchange transplantation of a pair of adrenal glands between the ep-mouse and the normal mouse followed by the successive administration of the adrenal ...
Kasahara, Junzi
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Critical Role of CT Imaging in Detecting Acute Neurological Complications of Eclampsia: A Case Series

Obgynia
Introduction: An intracranial hemorrhage (ICH) is a rare condition but potentially life-threatening event, especially in pregnancy, and could happen in patients with eclampsia.
Ayu Angelina Ronosulistyo, Zulvayanti Zulvayanti, Dini Hidayat, Windi Nurdiawan, Hadi Susiarno, Dini Pusianawati , Vyanda Sri Weningtyas   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Imipenem associated convulsion: Case report [PDF]

, 2007
Beta-laktam grubu antibiyotiklerinin nadir görülen yan etkilerinden biri de konvülziyondur. Acil servise yüksek atefl, öksürük ve solunum s›k›nt›s›yla gelen dokuz yafl›nda erkek hasta ampiyem tan›s›yla yat›r›lm›fl, ampiyem materyalinden yap›lan kültürde
Ayaz, Celal, Avcı, Alper, Üstün, Cemal, Geyik, Mehmet Faruk, Parlak, Zafer   +4 more
core   +1 more source

Quality of Life in Children with Epilepsy: A Bibliometric Analysis

Archives of Epilepsy
Objective: The aim of this study was to explore research related to the quality of life (QOL) of children with epilepsy using bibliometric analysis. Methods: This study used the Web of Science Core Collection database.
Kızbes Meral Kılıç, Hilal Aydın
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cyto-architectonic and Histochemical Studies of the Nucleus Lenticularis in Cats' Brain with Sepcial Reference to Convulsion Part Ⅱ. Histochemical Study of Cholinesterase in Areas of the Nucleus Lenticularis of Cats with Convulsion [PDF]

, 1958
Ten percent pentazol solution was experimentally injected in cats and the changes of cholinesterase (ChE) at the maximum stage of convulsion was histochemically investigated by Koelle modification: 1) The distribution of ChE was denser in convulsion ...
Honda, Kazuyuki
core