Results 71 to 80 of about 3,475,856 (338)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Transitions between homophilic and heterophilic modes of cooperation

, 2015
Cooperation is ubiquitous in biological and social systems. Previous studies revealed that a preference toward similar appearance promotes cooperation, a phenomenon called tag-mediated cooperation or communitarian cooperation.
Bersini, Hugues, Ichinose, Genki, Saito, Masaya, Sayama, Hiroki   +3 more
core   +1 more source

Oil and international cooperation [PDF]

, 2015
The more that states depend on oil exports, the less cooperative they become: they grow less likely to join intergovernmental organizations, to accept the compulsory jurisdiction of international judicial bodies, and to agree to binding arbitration for ...
Ross, ML, Voeten, E
core   +2 more sources

An Asia-Pacific Model of Development Cooperation [PDF]

Part One of the Osaka Action Agenda has clarified the implications of the basic political commitment to free and open trade and investment in the Bogor Declaration and has set out operational guiding principles and a well-developed strategy of ...
Foundation for Development Cooperation
core   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Educating Higher Education Students for Innovative Economies: What International Data Tell Us

Tuning Journal for Higher Education, 2014
As innovation increasingly fuels economic growth, higher education institutions and systems face the challenge of equipping students with the skills required by innovative economies.
Francesco Avvisati, Gwenaël Jacotin, Stéphan Vincent-Lancrin   +2 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Evolution of cooperation driven by zealots [PDF]

, 2012
Recent experimental results with humans involved in social dilemma games suggest that cooperation may be a contagious phenomenon and that the selection pressure operating on evolutionary dynamics (i.e., mimicry) is relatively weak.
A Iwagami, A Szolnoki, A Traulsen, A Traulsen, B Greiner, C Hauert, D Centola, DJ Rankin, G Szabó, GS van Doorn, H Ohtsuki, IM Hamilton, J Xie, JH Fowler, JS Coleman, K Chatterjee, L Blume, L Stanca, LD Molm, M Dufwenberg, M Mobilia, M Mobilia, MA Nowak, MA Nowak, MA Nowak, N Masuda, O Kirchkamp, P Singh, PE Oliver, R Boyd, R Willer, S Galam, T Yamagishi, Z Barta   +33 more
core   +1 more source

A Parallel Structured Adaptive Mesh Refinement Approach for Complex Turbulent Shear Flows

Journal of Fluid Science and Technology, 2012
In numerical fluid dynamic simulations, adaptive mesh refinement (AMR) approaches have recently been growing in popularity, particularly when the target flow field includes complex turbulent shear flows such as jets, mixing layers, and shear layers in ...
Yuichi MATSUO, Takuhito KUWABARA, Ichiro NAKAMORI   +2 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source