Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Aquachlorido(2-{[6-(dimethylamino)pyrimidin-4- yl]sulfanyl}pyrimidine-4,6-diamine)copper(II) chloride hydrate [PDF]
, 2017 A copper(II) complex of the non-symmetric bidentate ligand 2-{[6-(dimethylamino)pyrimidin-4-yl]sulfanyl}pyrimidine-4,6-diamine (L1) is reported. The single-crystal X-ray structure of aqua[aqua/chlorido(0.49/0.51)](2-{[6-(dimethylamino)pyrimidin-
Chan, Weibin +4 more
core +3 more sources
Rational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo
Nature Communications, 2021 Most fluorescence probes to measure hypoxia are irreversible. Here, the authors develop a near infrared luminescent probe to measure hypoxia which is reversible and use the probe to monitor hypoxia-reoxygenation in several animal models.
Yuming Zhang +13 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Koordinationschemie -gebundener Cyclopentadienyl-Chalkogeno-Ether [PDF]
, 1990 Coordination Chemistry of rr-Bonded Cyclopentadienyl Chalcogeno Ethers, I. - Chelate Complexes of Pentakis(methylthio)cymantrene with Metal Carbonyls [C5(SMe)5]Mn(CO)3 (1) reacts with W(CO)5(THF), Mo(CO)4(C7H8), Cr(CO)3(NCMe)3, and Re(CO)4(-C3H5)/HBF4 ...
Abel +27 more
core +1 more source
A practical fluorosulfonylating platform via photocatalytic imidazolium-based SO2F radical reagent
Nature Communications, 2022 Sulfonyl fluorides have potential application in chemical biology, materials science, and drug discovery, but their preparation remains challenging.
Weigang Zhang +9 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
SBE-type metal-substituted aluminophosphates: detemplation and coordination chemistry [PDF]
, 2009 The detemplation process in Me-SBE (Me = Co^2+, Mg^2+, and Mn^2+) aluminophosphates was studied to elucidate materials stability and framework characteristics.
Belén-Cordero, Daphne S. +3 more
core +1 more source
Polynuclear ampyrone based 3d coordination clusters [PDF]
, 2018 The use of the monoanionic Schiff base ligand (E)-4-(2-hydroxybenzylideneamino)-2,3-dimethyl-1-phenyl-1,2-dihydropyrazol-5-one in transition (Co, Ni and Cu) coordination chemistry yields mono-, tetra- and pentanuclear Coordination Clusters with different
Abdul-Sada, Alaa +9 more
core +1 more source