Results 1 to 10 of about 404,062 (356)

Developing a patient-driven chronic obstructive pulmonary disease (COPD) research agenda in the U.S.

Journal of Patient-Reported Outcomes, 2021
Plain English summary The COPD Patient-Powered Research Network (PPRN) asked adults with COPD and their caregivers to suggest areas for future research on COPD.
Inga Gruß, Gretchen M. McCreary, Ilya Ivlev, Mary Ellen Houlihan, Barbara P. Yawn, Cara Pasquale, William Clark, Richard A. Mularski   +7 more
doaj   +1 more source

Knowledge and Attitudes Concerning Herpes Zoster among People with COPD: An Interventional Survey Study

Vaccines, 2022
Herpes zoster (HZ) is common in older adults with conditions such as chronic obstructive pulmonary disease (COPD). Effective prevention is available through vaccination, but HZ vaccine uptake remains incomplete. Using an online survey of people with self-
Barbara P. Yawn, Debora D. Merrill, Sergio Martinez, Elisabeth Callen, Janice Cotton, Dennis Williams, Natalia Y. Loskutova   +6 more
doaj   +1 more source

The relation between age and airway epithelial barrier function

Respiratory Research, 2022
Background The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world.
M. de Vries, K. O. Nwozor, K. Muizer, M. Wisman, W. Timens, M. van den Berge, A. Faiz, T.-L. Hackett, I. H. Heijink, C. A. Brandsma   +9 more
doaj   +1 more source

T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways

Respiratory Research, 2016
Background Airway epithelial cells (AECs) are crucial for mucosal and adaptive immunity but whether these cells respond in a memory-dependent manner is poorly studied.
Hitendra S. Chand, Yohannes A. Mebratu, Marena Montera, Yohannes Tesfaigzi   +3 more
doaj   +1 more source

Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis

Respiratory Research, 2021
Background Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently, a causal link between mucus hyper-
Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E. G. W. Vanfleteren, Melker Göransson   +6 more
doaj   +1 more source

Addiction to tobacco smoking and vaping

Revista de Investigación Clínica, 2023
The tobacco epidemic has been one of the biggest public health threats, and smoking is one of the world’s largest preventable causes of premature death. An estimated 15.4% of all deaths in the world are attributable to tobacco smoking. The present review
Andrea Hernández-Pérez, Leonor García-Gómez, Robinson Robles-Hernández, Ireri Thirión-Romero, Jennifer Osio-Echánove, Sebastián Rodríguez-Llamazares, Ruben Baler, Rogelio Pérez-Padilla   +7 more
doaj   +1 more source

Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote disease ...
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux   +7 more
doaj   +1 more source

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

European Respiratory Review, 2015
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence ...
Bartolome R. Celli, Marc Decramer, Jadwiga A. Wedzicha, Kevin C. Wilson, Alvar A. Agustí, Gerard J. Criner, William MacNee, Barry J. Make, Stephen I. Rennard, Robert A. Stockley, Claus Vogelmeier, Antonio Anzueto, David H. Au, Peter J. Barnes, Pierre-Regis Burgel, Peter M. Calverley, Ciro Casanova, Enrico M. Clini, Christopher B. Cooper, Harvey O. Coxson, Daniel J. Dusser, Leonardo M. Fabbri, Bonnie Fahy, Gary T. Ferguson, Andrew Fisher, Monica J. Fletcher, Maurice Hayot, John R. Hurst, Paul W. Jones, Donald A. Mahler, François Maltais, David M. Mannino, Fernando J. Martinez, Marc Miravitlles, Paula M. Meek, Alberto Papi, Klaus F. Rabe, Nicolas Roche, Frank C. Sciurba, Sanjay Sethi, Nikos Siafakas, Don D. Sin, Joan B. Soriano, James K. Stoller, Donald P. Tashkin, Thierry Troosters, Geert M. Verleden, Johny Verschakelen, Jorgen Vestbo, John W. Walsh, George R. Washko, Robert A. Wise, Emiel F.M. Wouters, Richard L. ZuWallack   +53 more
doaj   +1 more source

STOP: an open label crossover trial to study ICS withdrawal in patients with a combination of obesity and low-inflammatory asthma and evaluate its effect on asthma control and quality of life

BMC Pulmonary Medicine, 2022
Background Asthma patients with obesity often have a high disease burden, despite the use of high-dose inhaled corticosteroids (ICS). In contrast to asthmatics with normal weight, the efficacy of ICS in patients with obesity and asthma is often ...
Jan A. Witte, Gert-Jan Braunstahl, Wouter J. B. Blox, Susan C. van ’t Westeinde, Johannes C. C. M. in ’t Veen, Jasper H. Kappen, Elisabeth F. C. van Rossum   +6 more
doaj   +1 more source

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Nature Communications, 2017
Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi   +6 more
doaj   +1 more source