Results 1 to 10 of about 602,916 (384)

Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients [PDF]

, 2012
Background: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells ...
A Aderem, A Biragyn, A Bruno, A Busacker, A Kato, AL Cozens, Angela Marina Montalbano, C Herr, CJ Murray, CY Kao, D Droemann, D Miotto, Dominik Hartl, E Doz, E Pace, E Pace, E Pace, E Pace, E Pace, Elisabetta Pace, F Niyonsaba, G Chiappara, Giuseppina Chiappara, J Pons, JC Hogg, JL Curtis, JL Imler, K Fellerman, K Kolble, L Petecchia, Liboria Siena, LM Hamilton, Loredana Pipitone, M Saetta, Malcolm Johnson, Maria Ferraro, Mark Gjomarkaj, Marta Ida Minervini, MG Cosio, N Kanda, Patrizio Vitulo, Q Sha, R MacRedmond, R O'Donnell, S Boodoo, S Sethi, S Sethi, SD Sullivan, TS Lapperre, V Kim, W Zhang, X Zhang   +51 more
core   +14 more sources

Developing a patient-driven chronic obstructive pulmonary disease (COPD) research agenda in the U.S.

Journal of Patient-Reported Outcomes, 2021
Plain English summary The COPD Patient-Powered Research Network (PPRN) asked adults with COPD and their caregivers to suggest areas for future research on COPD.
Inga Gruß, Gretchen M. McCreary, Ilya Ivlev, Mary Ellen Houlihan, Barbara P. Yawn, Cara Pasquale, William Clark, Richard A. Mularski   +7 more
doaj   +1 more source

The relation between age and airway epithelial barrier function

Respiratory Research, 2022
Background The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world.
M. de Vries, K. O. Nwozor, K. Muizer, M. Wisman, W. Timens, M. van den Berge, A. Faiz, T.-L. Hackett, I. H. Heijink, C. A. Brandsma   +9 more
doaj   +1 more source

Knowledge and Attitudes Concerning Herpes Zoster among People with COPD: An Interventional Survey Study

Vaccines, 2022
Herpes zoster (HZ) is common in older adults with conditions such as chronic obstructive pulmonary disease (COPD). Effective prevention is available through vaccination, but HZ vaccine uptake remains incomplete. Using an online survey of people with self-
Barbara P. Yawn, Debora D. Merrill, Sergio Martinez, Elisabeth Callen, Janice Cotton, Dennis Williams, Natalia Y. Loskutova   +6 more
doaj   +1 more source

T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways

Respiratory Research, 2016
Background Airway epithelial cells (AECs) are crucial for mucosal and adaptive immunity but whether these cells respond in a memory-dependent manner is poorly studied.
Hitendra S. Chand, Yohannes A. Mebratu, Marena Montera, Yohannes Tesfaigzi   +3 more
doaj   +1 more source

Addiction to tobacco smoking and vaping

Revista de Investigación Clínica, 2023
The tobacco epidemic has been one of the biggest public health threats, and smoking is one of the world’s largest preventable causes of premature death. An estimated 15.4% of all deaths in the world are attributable to tobacco smoking. The present review
Andrea Hernández-Pérez, Leonor García-Gómez, Robinson Robles-Hernández, Ireri Thirión-Romero, Jennifer Osio-Echánove, Sebastián Rodríguez-Llamazares, Ruben Baler, Rogelio Pérez-Padilla   +7 more
doaj   +1 more source

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep [PDF]

, 2006
Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large- animal model of emphysema using repeated LPS administration into sheep lung segments. An
Baker, Alison, Blundell, Richard, Collie, D David S, McLean, Nicola, Milne, Elspeth, Rhind, Susan, Sallenave, Jean-Michel, Woodall, Chris   +7 more
core   +2 more sources

Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis

Respiratory Research, 2021
Background Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently, a causal link between mucus hyper-
Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E. G. W. Vanfleteren, Melker Göransson   +6 more
doaj   +1 more source

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote disease ...
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux   +7 more
doaj   +1 more source