Results 1 to 10 of about 200,765 (90)

Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients [PDF]

, 2012
Background: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells ...
A Aderem, A Biragyn, A Bruno, A Busacker, A Kato, AL Cozens, Angela Marina Montalbano, C Herr, CJ Murray, CY Kao, D Droemann, D Miotto, Dominik Hartl, E Doz, E Pace, E Pace, E Pace, E Pace, E Pace, Elisabetta Pace, F Niyonsaba, G Chiappara, Giuseppina Chiappara, J Pons, JC Hogg, JL Curtis, JL Imler, K Fellerman, K Kolble, L Petecchia, Liboria Siena, LM Hamilton, Loredana Pipitone, M Saetta, Malcolm Johnson, Maria Ferraro, Mark Gjomarkaj, Marta Ida Minervini, MG Cosio, N Kanda, Patrizio Vitulo, Q Sha, R MacRedmond, R O'Donnell, S Boodoo, S Sethi, S Sethi, SD Sullivan, TS Lapperre, V Kim, W Zhang, X Zhang   +51 more
core   +14 more sources

Women's COPD [PDF]

Frontiers in Medicine, 2022
Chronic obstructive pulmonary disease (COPD) is no longer a respiratory disease that predominantly affects men, to the point where the prevalence among women has equaled that of men since 2008, partly due to their increasing exposure to tobacco and to biomass fuels. Indeed, COPD has become the leading cause of death in women in the USA.
Maéva Zysman, Maéva Zysman, Chantal Raherison-Semjen, Chantal Raherison-Semjen   +3 more
openaire   +4 more sources

Comorbidities of COPD [PDF]

European Respiratory Review, 2013
By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer.
Cavaillès, Arnaud, Brinchault-Rabin, Graziella, Dixmier, Adrien, Goupil, François, Gut-Gobert, Christophe, Marchand-Adam, Sylvain, Meurice, Jean-Claude, Morel, Hugues, Person-Tacnet, Christine, Leroyer, Christophe, Diot, Patrice   +10 more
openaire   +7 more sources

COPD immunopathology [PDF]

Seminars in Immunopathology, 2016
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched ...
CARAMORI, Gaetano, CASOLARI, Paolo, Barczyk, Adam, Durham, Andrew L, Di Stefano, Antonino, Adcock, Ian   +5 more
openaire   +5 more sources

Sphingolipids in COPD [PDF]

European Respiratory Review, 2019
Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators
Raja Chandra Chakinala, Akshay Khatri, Kriti Gupta, Kengo Koike, Oleg Epelbaum   +4 more
openaire   +3 more sources

Treatments for COPD [PDF]

Respiratory Medicine, 2005
The multicomponent nature of chronic obstructive pulmonary disease (COPD) has provided a challenging environment in which to develop successful treatments. A combination of pharmacological and non-pharmacological approaches is used to combat this problem, and an overview of these approaches and their possible future direction is given.
Hanania, Nicola A., Ambrosino, Nicolino, Calverley, Peter, Cazzola, Mario, Donner, Claudio F, Make, Barry   +5 more
openaire   +4 more sources

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep [PDF]

, 2006
Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large- animal model of emphysema using repeated LPS administration into sheep lung segments. An
Baker, Alison, Blundell, Richard, Collie, D David S, McLean, Nicola, Milne, Elspeth, Rhind, Susan, Sallenave, Jean-Michel, Woodall, Chris   +7 more
core   +2 more sources

Women with COPD [PDF]

Breathe, 2020
Health inequalities regarding gender are extremely prevalent, and specifically in conditions such as COPD. No woman should ever be dismissed in regard to their health and underlying medical history. https://bit.ly/2X7Klmd.
Jessica Denning, Isabel Saraiva, R. Andrew McIvor, Emma R. McIvor   +3 more
openaire   +3 more sources

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Objective measurement of cough frequency during COPD exacerbation convalescence [PDF]

, 2015
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD).
Crooks, Michael G., Hayman, Yvette, Innes, Andrew, Morice, Alyn H., Williamson, James, Wright, Caroline E.   +5 more
core   +1 more source