Results 1 to 10 of about 28,053 (261)

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches [PDF]

Advanced Science
Despite advances in understanding the STING signaling pathway, mechanisms governing cyclic GMP‐AMP (cGAMP)‐induced STING trafficking out of the endoplasmic reticulum (ER) remain unclear.
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
doaj   +3 more sources

Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway

Frontiers in Cell and Developmental Biology, 2021
The coat protein complex II (COPII) mediates forward trafficking of protein and lipid cargoes from the endoplasmic reticulum. COPII is an ancient and essential pathway in all eukaryotes and COPII dysfunction underlies a range of human diseases.
Brittany J. Bisnett, Brett M. Condon, Caitlin H. Lamb, George R. Georgiou, Michael Boyce   +4 more
doaj   +2 more sources

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles

iScience, 2023
Summary: G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma membrane signaling proteins. However, virtually nothing is known about their recruitment to COPII vesicles for forward delivery after synthesis in the endoplasmic ...
Xin Xu, Nevin A. Lambert, Guangyu Wu
doaj   +2 more sources

Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport

Nature Communications, 2023
Co-assembly of the multilayered coat protein complex II (COPII) with the Sar1 GTPase at subdomains of the endoplasmic reticulum (ER) enables secretory cargoes to be concentrated efficiently within nascent transport intermediates, which subsequently ...
William Kasberg, Peter Luong, Kevin A. Swift, Anjon Audhya   +3 more
doaj   +2 more sources

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

Science, 2019
ER-phagy keeps cells healthy In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui et al. studied a protein known as Lst1 in yeast
Yixian Cui, Smriti Parashar, Muhammad Zahoor   +2 more
exaly   +2 more sources

COPII mitigates ER stress by promoting formation of ER whorls

Cell Research, 2020
Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report formation of ER whorls as an effector mechanism of the ER stress response.
Xin Zhang, Wenhao Zhang, Haiteng Deng
exaly   +2 more sources

SEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation. [PDF]

Adv Sci (Weinh)
Autophagy plays an important role in determining stem‐cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown.
Nie J, Ma S, Wu L, Li Y, Cao J, Li M, Mei P, Cooper PR, Li A, Pei D.   +9 more
europepmc   +2 more sources

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes. [PDF]

Nat Struct Mol Biol
Proteins traverse the eukaryotic secretory pathway through membrane trafficking between organelles. The COPII coat mediates the anterograde transport of newly synthesised proteins from the endoplasmic reticulum, engaging cargoes with a wide range of size
Pyle E, Miller EA, Zanetti G.
europepmc   +2 more sources

COPII‐mediated trafficking at the ER/ERGIC interface

Traffic, 2019
Coat proteins play multiple roles in the life cycle of a membrane‐bound transport intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an acceptor compartment. The Coat Protein complex II (COPII) coat is known to act in
Anjon Audhya
exaly   +2 more sources

Tuberculoza rezistentă la copii.

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2020
Introducere. OMS estimează în 2020 1 mln copii bolnavi de tuberculoză (TB), 25000 cu TB rezistentă, doar 10% fiind diagnosticați și tratați. TB rezistentă la copii este primară.
Stela Kulciţchi
doaj   +3 more sources