Results 1 to 10 of about 5,935 (149)

COP-coated vesicles [PDF]

Current Biology, 2016
Approximately one third of a cell's proteins are destined to function outside the cell's boundaries or while embedded within cellular membranes. Ensuring these proteins reach their diverse final destinations with temporal and spatial accuracy is essential for cellular physiology.
Gomez-Navarro, Natalia, Miller, Elizabeth A.   +1 more
openaire   +4 more sources

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection. [PDF]

New Phytol
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Cana-Quijada P, Morales-Martínez P, Rosas-Díaz T, Pérez-Sancho J, Jiménez-Góngora T, Navarro JA, Lozano-Durán R, Castillo AG, Pallás V, Bejarano ER.   +9 more
europepmc   +2 more sources

Trafficking of the human Na⁺/H⁺ antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors. [PDF]

Protein Sci
Abstract A key prerequisite of transporter proteins' function is their trafficking to the target cellular membranes where they fulfill distinct physiological roles. Cornichon proteins (CNIH/Erv14) represent a highly conserved family of coat protein complex II (COPII)‐coated vesicle cargo receptors that facilitate the exit of numerous transporters from ...
Kacovská K, Papoušková K, Masrati G, Rosas-Santiago P, Przeczková T, Žárská V, Ben-Tal N, Zimmermannová O.   +7 more
europepmc   +2 more sources

Proteomic and Lipidomic Profiling of Immune Cell-Derived Subpopulations of Extracellular Vesicles. [PDF]

Proteomics
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Lischnig A, Karimi N, Larsson P, Ekström K, Crescitelli R, Olin AC, Lässer C.   +6 more
europepmc   +2 more sources

Cex1 is a component of the COPI intracellular trafficking machinery

Biology Open, 2021
COPI (coatomer complex I) coated vesicles are involved in Golgi-to-ER and intra-Golgi trafficking pathways, and mediate retrieval of ER resident proteins. Functions and components of the COPI-mediated trafficking pathways, beyond the canonical set of Sec/
Ludovic Enkler, Bruno Rinaldi, Johan Owen de Craene, Philippe Hammann, Osamu Nureki, Bruno Senger, Sylvie Friant, Hubert D. Becker   +7 more
doaj   +1 more source

En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles. [PDF]

The Journal of cell biology, 1994
The cDNA encoding epsilon-COP, the 36-kD subunit of coatomer, was cloned from a bovine liver cDNA library and sequenced. Immunoblotting with an anti-epsilon-COP antibody showed that epsilon-COP exists in COP-coated vesicles as well as in the cytosolic coatomer.
S, Hara-Kuge, O, Kuge, L, Orci, M, Amherdt, M, Ravazzola, F T, Wieland, J E, Rothman   +6 more
openaire   +2 more sources

Loss of Arabidopsis β-COP Function Affects Golgi Structure, Plant Growth and Tolerance to Salt Stress

Frontiers in Plant Science, 2020
The early secretory pathway involves bidirectional transport between the endoplasmic reticulum (ER) and the Golgi apparatus and is mediated by coat protein complex I (COPI)-coated and coat protein complex II (COPII)-coated vesicles.
Judit Sánchez-Simarro, César Bernat-Silvestre, Fátima Gimeno-Ferrer, Pilar Selvi-Martínez, Javier Montero-Pau, Fernando Aniento, María Jesús Marcote   +6 more
doaj   +1 more source

A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

Life Science Alliance, 2020
The paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.
Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune   +8 more
doaj   +1 more source

The spinal muscular atrophy disease protein SMN is linked to the Golgi network. [PDF]

PLoS ONE, 2012
Proximal spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by deficiency of the ubiquitous Survival of Motor Neuron (SMN) protein. SMN has been shown to be transported in granules along the axon and moved through cytoskeletal elements.
Chen-Hung Ting, Hsin-Lan Wen, Hui-Chun Liu, Hsiu-Mei Hsieh-Li, Hung Li, Sue Lin-Chao   +5 more
doaj   +1 more source

The complexity of vesicle transport factors in plants examined by orthology search. [PDF]

PLoS ONE, 2014
Vesicle transport is a central process to ensure protein and lipid distribution in eukaryotic cells. The current knowledge on the molecular components and mechanisms of this process is majorly based on studies in Saccharomyces cerevisiae and Arabidopsis ...
Puneet Paul, Stefan Simm, Oliver Mirus, Klaus-Dieter Scharf, Sotirios Fragkostefanakis, Enrico Schleiff   +5 more
doaj   +1 more source