Results 21 to 30 of about 5,935 (149)

Silkworm coatomers and their role in tube expansion of posterior silkgland.

open access: yesPLoS ONE, 2010
BackgroundCoat protein complex I (COPI) vesicles, coated by seven coatomer subunits, are mainly responsible for Golgi-to-ER transport. Silkworm posterior silkgland (PSG), a highly differentiated secretory tissue, secretes fibroin for silk production, but
Qiao Wang   +9 more
doaj   +1 more source

A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]

open access: yes, 2017
Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David   +12 more
core   +2 more sources

9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

open access: yeseLife, 2017
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane ...
Svetlana O Dodonova   +8 more
doaj   +1 more source

"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]

open access: yes, 2007
Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core   +1 more source

An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]

open access: yes, 2003
The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B.   +7 more
core   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

open access: yes, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E.   +4 more
core   +2 more sources

Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes [PDF]

open access: yes, 1992
A mAb AD7, raised against canine liver Golgi membranes, recognizes a novel, 200-kD protein (p200) which is found in a wide variety of cultured cell lines.
Burke, B.   +6 more
core   +1 more source

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes [PDF]

open access: yes, 1996
In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes.
Aniento, F.   +3 more
core   +1 more source

Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2.

open access: yesPLoS ONE, 2017
The transmembrane emp24 domain/p24 (TMED) family are essential components of the vesicular transport machinery. Members of the TMED family serve as cargo receptors implicated in selection and packaging of endoplasmic reticulum (ER) luminal proteins into ...
Wenyang Hou   +4 more
doaj   +1 more source

Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes [PDF]

open access: yes, 1927
Membrane traffic between the endoplasmic reticulum (ER) and the Golgi complex is regulated by two vesicular coat complexes, COPII and COPI. COPII has been implicated in the selective packaging of anterograde cargo into coated transport vesicles budding ...
Shima, David T.   +3 more
core   +1 more source

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