Results 121 to 130 of about 28,053 (261)

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways [PDF]

, 2013
Vesicle trafficking systems play essential roles in the communication between the organelles of eukaryotic cells and also between cells and their environment.
A Fotin, A Fotin, A Pagano, A Reider, A Spang, A Wesp, AC Baines, B Eisenhaber, B Meszaros, B Wendland, BA Shoemaker, BG Yeung, BM Collins, C Brocker, C Gurkan, C Kalthoff, C Lee, CG Giraudo, CJ Brown, CL Allen, D Berdnik, D Kummel, D Szklarczyk, DA Shaywitz, E Schad, E ter Haar, EC Dell'Angelica, EC Dimmer, ET Wang, G Ostlund, GS Payne, H Cai, H Folsch, H Hegyi, H Xie, HJ Dyson, HM Ngo, HT McMahon, I von Ossowski, J Bethune, J Malsam, J Moelleken, J Ren, JD Wilbur, JE Gerst, JL Sussman, JR Schaub, K Sato, LM Iakoucheva, Luhua Lai, M Buljan, M Fuxreiter, M Gonzalez-Gaitan, M Punta, MS Robinson, Natalia Pietrosemoli, ND Dwyer, NE Davey, P Flicek, P Tompa, P Tompa, P Tompa, PE Wright, Peter Tompa, PR Evans, R Beck, R Jahn, R Pancsa, R Pancsa, R Sannerud, Rita Pancsa, RJ Weatheritt, RJ Weatheritt, S Fath, SJ Royle, SM Stagg, SM Stagg, SM Stagg, T Kirchhausen, TC Sudhof, TJ Brett, TM Newpher, TR Dafforn, U Consortium, U Scheele, V Legendre-Guillemin, VN Murthy, VW Hsu, W Li, X Chen, Y Lefkir, Y Zhuo, Z Dosztanyi, Z Dosztanyi, Z Dosztanyi   +94 more
core   +3 more sources

COPII Components Sar1b and Sar1c Play Distinct Yet Interchangeable Roles in Pollen Development1[OPEN]

Plant Physiology, 2020
The small GTPase Sar1, a component of the COPII complex that mediates vesicular trafficking from ER to Golgi, participates in sporophytic and gametophytic control of pollen development in Arabidopsis, with different isoforms playing distinct or redundant
Xin Liang, Sha Li, Li-Min Gong, Sha Li, Yan Zhang   +4 more
semanticscholar   +1 more source

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

COPILUL CU AFECŢIUNI ONCOLOGICE ÎN TERAPIA INTENSIVĂ [PDF]

Romanian Journal of Pediatrics, 2012
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care pacientul poate ...
N. Nistor, Georgiana Russu, Ingrith Miron, Irina-Mihaela Ciomaga, Cristina Jităreanu, Violeta Ştreangă   +5 more
doaj   +1 more source

Functional analysis of SFT-4/Surf4 family proteins in the biogenesis and secretion of lipoproteins [PDF]

, 2018
学位記番号 ...
Saegusa, Keiko, サエグサ, ケイコ, 三枝, 慶子   +2 more
core  

Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: Commonalities, differences, challenges [PDF]

, 2011
The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups).
Leksa, Nina Carolina, Schwartz, Thomas
core   +1 more source

Hepatitis B subviral envelope particles use the COPII machinery for intracellular transport via selective exploitation of Sec24A and Sec23B

Cellular Microbiology, 2020
Hepatitis B virus (HBV) is a leading cause of liver disease. Its success as a human pathogen is related to the immense production of subviral envelope particles (SVPs) contributing to viral persistence by interfering with immune functions.
L. Zeyen, Tatjana Döring, J. Stieler, R. Prange   +3 more
semanticscholar   +1 more source

Using Mathematical Modeling of Tumor Metabolism to Predict the Magnitude, Composition, and Hypoxic Interactions of Microenvironment Acidosis

BioEssays, Volume 48, Issue 1, January 2026.
Mathematical model of a perfused cylindrical tumor predicts venous‐end extracellular [O2], pH, [CO2], and [HCO3−] in the case of either fermentative or respiratory metabolism, illustrating the relationship between hypoxia and acidosis and the chemical composition of acidosis in the tumor microenvironment. ABSTRACT In well‐perfused tissues, interstitial
Alzbeta Hulikova, Pawel Swietach
wiley   +1 more source

Molecular architecture of the Nup84–Nup145C–Sec13 edge element in the nuclear pore complex lattice [PDF]

, 2009
Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components.
A Fotin, A Harel, AGW Leslie, AJ McCoy, AM Waterhouse, AT Brünger, BV Strokopytov, C Vonrhein, CS Bond, D Devos, D Devos, D Stoffler, E Dultz, E Fabre, E Krissinel, E Krissinel, E Onischenko, EJ Tran, EW Debler, F Alber, G Drin, G Rabut, GA Ratner, GM Sheldrick, HT McMahon, IC Berke, J Zimmerberg, JR Whittle, K Weis, KC Hsia, M Beck, M Kampmann, M Lutzmann, M Lutzmann, MA D'Angelo, MP Rout, MP Rout, N Elad, N Handa, N Schrader, NC Leksa, P Emsley, PD Adams, RC Edgar, S Fath, S Frey, S Jeudy, S Siniossoglou, SG Brohawn, SG Brohawn, SG Brohawn, SM Stagg, Stephen G Brohawn, T Boehmer, T Boehmer, T Makio, TC Walther, Thomas U Schwartz, TU Schwartz, V Galy, Y Jia, Y Shibata, Z Otwinowski   +62 more
core   +1 more source