Results 121 to 130 of about 28,140 (260)

A novel platform for the production of nonhydroxylated gelatins based on the methylotrophic yeast Hansenula polymorpha [PDF]

, 2007
The use of yeast as a host for heterologous expression of proteins that are normally derived from animal tissue is a promising way to ensure defined products that are devoid of potential harmful animal side products.
Boer, Arjo L. de,, Geerlings, Torsten H.,, Klei, Ida J. van der,, Lunenborg, Marcel G.J.,, Veenhuis, Marten,   +4 more
core   +2 more sources

Using Mathematical Modeling of Tumor Metabolism to Predict the Magnitude, Composition, and Hypoxic Interactions of Microenvironment Acidosis

BioEssays, Volume 48, Issue 1, January 2026.
Mathematical model of a perfused cylindrical tumor predicts venous‐end extracellular [O2], pH, [CO2], and [HCO3−] in the case of either fermentative or respiratory metabolism, illustrating the relationship between hypoxia and acidosis and the chemical composition of acidosis in the tumor microenvironment. ABSTRACT In well‐perfused tissues, interstitial
Alzbeta Hulikova, Pawel Swietach
wiley   +1 more source

COPILUL CU AFECŢIUNI ONCOLOGICE ÎN TERAPIA INTENSIVĂ [PDF]

Romanian Journal of Pediatrics, 2012
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care pacientul poate ...
N. Nistor, Georgiana Russu, Ingrith Miron, Irina-Mihaela Ciomaga, Cristina Jităreanu, Violeta Ştreangă   +5 more
doaj   +1 more source

Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways [PDF]

, 2013
Vesicle trafficking systems play essential roles in the communication between the organelles of eukaryotic cells and also between cells and their environment.
A Fotin, A Fotin, A Pagano, A Reider, A Spang, A Wesp, AC Baines, B Eisenhaber, B Meszaros, B Wendland, BA Shoemaker, BG Yeung, BM Collins, C Brocker, C Gurkan, C Kalthoff, C Lee, CG Giraudo, CJ Brown, CL Allen, D Berdnik, D Kummel, D Szklarczyk, DA Shaywitz, E Schad, E ter Haar, EC Dell'Angelica, EC Dimmer, ET Wang, G Ostlund, GS Payne, H Cai, H Folsch, H Hegyi, H Xie, HJ Dyson, HM Ngo, HT McMahon, I von Ossowski, J Bethune, J Malsam, J Moelleken, J Ren, JD Wilbur, JE Gerst, JL Sussman, JR Schaub, K Sato, LM Iakoucheva, Luhua Lai, M Buljan, M Fuxreiter, M Gonzalez-Gaitan, M Punta, MS Robinson, Natalia Pietrosemoli, ND Dwyer, NE Davey, P Flicek, P Tompa, P Tompa, P Tompa, PE Wright, Peter Tompa, PR Evans, R Beck, R Jahn, R Pancsa, R Pancsa, R Sannerud, Rita Pancsa, RJ Weatheritt, RJ Weatheritt, S Fath, SJ Royle, SM Stagg, SM Stagg, SM Stagg, T Kirchhausen, TC Sudhof, TJ Brett, TM Newpher, TR Dafforn, U Consortium, U Scheele, V Legendre-Guillemin, VN Murthy, VW Hsu, W Li, X Chen, Y Lefkir, Y Zhuo, Z Dosztanyi, Z Dosztanyi, Z Dosztanyi   +94 more
core   +3 more sources

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

The yeast p24 complex regulates gpi-anchored protein Transport and quality control by monitoring anchor remodeling [PDF]

, 2011
Glycosylphosphatidylinositol (GPI)-anchored proteins are secretory proteins that are attached to the cell surface of eukaryotic cells by a glycolipid moiety.
Aguilera Romero, María Auxiliadora, Castillon, Guillaume Alain, Epsteina, Sharon, Funato, Kouichi, Kajiwarac, Kentaro, Manzano López, Javier, Muñiz Guinea, Manuel, Riezman, Howard, Watanabe, Reika   +8 more
core   +2 more sources

Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis

Small Science, Volume 6, Issue 1, January 2026.
Current temporomandibular joint osteoarthritis (TMJOA) treatments lack progression control. MicroRNAs (miRNAs) offer therapeutic potential but face delivery hurdles. A novel nanodelivery system is developed using tetrahedral framework nucleic acids functionalized with miR‐143‐3p (tFNAs‐143). Tested in TMJOA models and inflammatory conditions, tFNAs‐143
Wenxiu Yuan, Maotuan Huang, Linxin Chen, Sihang Chen, Hanyu Lin, Nengwen Huang, Yifeng Xing, Chengchaozi Wang, Jie Lu, Min Fu, Linyu Xu, Jiang Chen   +11 more
wiley   +1 more source

PARTICULARITĂȚILE SINDROMULUI METABOLIC LA COPII

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2022
Prevalența sindromului metabolic la copii este în creștere, în paralel cu tendințele în creștere ale ratelor de obezitate. Diferitele definiții ale acestui sindrom au împiedicat dezvoltarea unui consens pentru criteriile de diagnostic la populația pediatrică, în timp ce patogeneza sindromului metabolic nu este complet înțeleasă.
Cojocari, S.V., Mătrăgună, N.G.
openaire   +2 more sources

Cargo crowding contributes to sorting stringency in COPII vesicles

Journal of Cell Biology, 2020
Combining correlative light and electron microscopy with yeast genetics and biochemistry, Gomez-Navarro, Melero, and colleagues show that cargo recruitment into a constrained COPII vesicle restricts bulk flow, thereby contributing to sorting stringency ...
Natalia Gomez-Navarro, Alejandro Melero, Xiaohan Li, J. Boulanger, W. Kukulski, E. Miller   +5 more
semanticscholar   +1 more source

Heterologous Production of Cyprosin B in Nicotiana benthamiana: Unveiling the Role of the Plant‐Specific Insert Domain in Protein Function and Subcellular Localisation

Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.
ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy, Ramesh Raju Vetukuri, Anneli Lundgren, Sungyong Kim, Pruthvi B. Kalyandurg, Åke Strid, Li‐Hua Zhu, Selvaraju Kanagarajan, Peter E. Brodelius   +8 more
wiley   +1 more source