Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]
, 2010 We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Alcock F. +81 more
core +2 more sources
Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation
Advanced Science, Volume 12, Issue 45, December 4, 2025.A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo +10 more
wiley +1 more source
Plant Physiology, 2020 The small GTPase Sar1, a component of the COPII complex that mediates vesicular trafficking from ER to Golgi, participates in sporophytic and gametophytic control of pollen development in Arabidopsis, with different isoforms playing distinct or redundant
Xin Liang +4 more
semanticscholar +1 more source
Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment
Advanced Science, Volume 12, Issue 45, December 4, 2025.Soluble GRP78 (sGRP78) is identified as a novel tumor‐derived soluble factor that induces regulatory T cells (Treg). sGRP78 serves as an excellent serological biomarker for predicting the efficacy of neoadjuvant therapy in breast cancer patients. sGRP78 specifically binds to B cells, inducing the expression of IL‐10 and PD‐L1, thereby promoting Treg ...
Zhenghao Wu +10 more
wiley +1 more source
Structural studies of the ERGIC-53/MCFD2 glycoprotein transport receptor complex [PDF]
, 2012 The secretory pathway defines and maintains the intracellular architecture of the eukaryotic cell. Proteins targeted to either the plasma membrane, the extracellular medium or to specific organelles within the cell are dependent on the correct ...
Wigren, Edvard
core +1 more source
The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease
Brain and Behavior, Volume 15, Issue 12, December 2025.This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley +1 more source
Particularitățile adenomului și cancerului folicular al glandei tiroide la copii
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019 Au fost cercetate – particularitățile adenomului și cancerului folicular al glandei tiroide la copii în perioada anilor 2002-2018. Au fost supuși tratamentului chirurgical 31 de copii cu cancer folicular al glandei tiroide și 42 copii cu adenom folicular.
Andrei Ţîbîrnă +4 more
doaj
Louvre Museum - Paintings [PDF]
, 2018 The Louvre Museum is the largest of the world's art museums by its exhibition surface. These represent the Western art of the Middle Ages in 1848, those of the ancient civilizations that preceded and influenced it (Oriental, Egyptian, Greek, Etruscan and
Sfetcu, Nicolae
core
Dissection of GTPase activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]
, 2019 The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel, E. +5 more
core +1 more source
Functional analysis of SFT-4/Surf4 family proteins in the biogenesis and secretion of lipoproteins [PDF]
, 2018 学位記番号 ...
Saegusa, Keiko +2 more
core