Results 131 to 140 of about 28,053 (261)

PARTICULARITĂȚILE SINDROMULUI METABOLIC LA COPII

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2022
Prevalența sindromului metabolic la copii este în creștere, în paralel cu tendințele în creștere ale ratelor de obezitate. Diferitele definiții ale acestui sindrom au împiedicat dezvoltarea unui consens pentru criteriile de diagnostic la populația pediatrică, în timp ce patogeneza sindromului metabolic nu este complet înțeleasă.
Cojocari, S.V., Mătrăgună, N.G.
openaire   +2 more sources

Hepatitis B Virus Exploits ERGIC-53 in Conjunction with COPII to Exit Cells

Cells, 2020
Several decades after its discovery, the hepatitis B virus (HBV) still displays one of the most successful pathogens in human populations worldwide. The identification and characterization of interactions between cellular and pathogenic components are ...
L. Zeyen, Tatjana Döring, R. Prange
semanticscholar   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]

, 2019
Background: Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip. Additionally, both these processes require ATP and amino acid
Cairns, Timothy C., Feurstein, Claudia, Meyer, Vera, Sun, Jibin, Zhang, Li Hui, Zheng, Ping, Zheng, Xiaomei   +6 more
core   +1 more source

Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis

Small Science, Volume 6, Issue 1, January 2026.
Current temporomandibular joint osteoarthritis (TMJOA) treatments lack progression control. MicroRNAs (miRNAs) offer therapeutic potential but face delivery hurdles. A novel nanodelivery system is developed using tetrahedral framework nucleic acids functionalized with miR‐143‐3p (tFNAs‐143). Tested in TMJOA models and inflammatory conditions, tFNAs‐143
Wenxiu Yuan, Maotuan Huang, Linxin Chen, Sihang Chen, Hanyu Lin, Nengwen Huang, Yifeng Xing, Chengchaozi Wang, Jie Lu, Min Fu, Linyu Xu, Jiang Chen   +11 more
wiley   +1 more source

A novel platform for the production of nonhydroxylated gelatins based on the methylotrophic yeast Hansenula polymorpha [PDF]

, 2007
The use of yeast as a host for heterologous expression of proteins that are normally derived from animal tissue is a promising way to ensure defined products that are devoid of potential harmful animal side products.
Boer, Arjo L. de,, Geerlings, Torsten H.,, Klei, Ida J. van der,, Lunenborg, Marcel G.J.,, Veenhuis, Marten,   +4 more
core   +2 more sources

Heterologous Production of Cyprosin B in Nicotiana benthamiana: Unveiling the Role of the Plant‐Specific Insert Domain in Protein Function and Subcellular Localisation

Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.
ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy, Ramesh Raju Vetukuri, Anneli Lundgren, Sungyong Kim, Pruthvi B. Kalyandurg, Åke Strid, Li‐Hua Zhu, Selvaraju Kanagarajan, Peter E. Brodelius   +8 more
wiley   +1 more source

Dissection of GTPase activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]

, 2019
The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel, E., Estrada, A., Huranova, M., Rau, E., Schwappach, B., Spang, A.   +5 more
core   +1 more source

TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

eLife, 2018
Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen?
I. Raote, Maria Ortega-Bellido, António J. M. Santos, O. Foresti, Chong Zhang, M. Garcia-Parajo, F. Campelo, V. Malhotra   +7 more
semanticscholar   +1 more source

Combinatorial multivalent interactions drive cooperative assembly of the COPII coat

Journal of Cell Biology, 2020
Using in vitro reconstitution assays and in vivo cellular phenotypes, Stancheva and colleagues dissect the protein interaction network that drives COPII coat assembly during vesicle formation from the endoplasmic reticulum, revealing the importance of ...
Viktoriya G Stancheva, Xiaohan Li, J. Hutchings, Natalia Gomez-Navarro, Balaji Santhanam, M. Babu, G. Zanetti, E. Miller   +7 more
semanticscholar   +1 more source