Results 11 to 20 of about 28,140 (260)

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles

iScience, 2023
Summary: G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma membrane signaling proteins. However, virtually nothing is known about their recruitment to COPII vesicles for forward delivery after synthesis in the endoplasmic ...
Xin Xu, Nevin A. Lambert, Guangyu Wu
doaj   +2 more sources

Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport

Nature Communications, 2023
Co-assembly of the multilayered coat protein complex II (COPII) with the Sar1 GTPase at subdomains of the endoplasmic reticulum (ER) enables secretory cargoes to be concentrated efficiently within nascent transport intermediates, which subsequently ...
William Kasberg, Peter Luong, Kevin A. Swift, Anjon Audhya   +3 more
doaj   +2 more sources

HDAC-Specific Inhibitors Induce the Release of Porcine Epidemic Diarrhea Virus via the COPII-Coated Vesicles

Viruses, 2023
Porcine epidemic diarrhea virus (PEDV) is an alpha-coronavirus causing acute diarrhea and high mortality in neonatal suckling piglets, resulting in huge economic losses for the global swine industry.
Ying Yang, Huan Chen, Caisheng Zhang, Hyun-Jin Shin, Yingjuan Qian, Yong-Sam Jung   +5 more
doaj   +2 more sources

The COPII Transport Complex Participates in HPV16 Infection. [PDF]

Viruses
Human papillomavirus (HPV) 16 is transported in a retrograde fashion from the cell surface to the Golgi apparatus. Prior to mitosis, the virus loses association with the Golgi and, following nuclear envelope breakdown, is found associated with the ...
Day PM, Thompson CD, Weisberg AS, Schiller JT.   +3 more
europepmc   +2 more sources

TMEM131-Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation-Induced Lung Injury. [PDF]

Adv Sci (Weinh)
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Han L, Wang C, Guo X, Luo Y, Zhang J, He F, Zeng Z, Luo J, Ouyang W, Gong Y, Xie C.   +10 more
europepmc   +2 more sources

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway. [PDF]

Nat Rev Mol Cell Biol
Downes KW, Zanetti G.
europepmc   +2 more sources

FENOMENE AUTOIMUNE DE OVERLAP ÎN HEPATITELE CRONICE ALE COPILULUI [PDF]

Romanian Journal of Pediatrics, 2012
Pacienţii cu hepatopatii cronice pot prezenta fenomene imunologice serologice sau chiar un veritabil sindrom de overlap. Aceste sindroame prezintă caractere comune biochimice şi histopatologice pentru cel puţin două dintre afecţiunile autoimune ...
Daniela Păcurar, Gabriela Leşanu, Cristina Becheanu, Raluca Vlad, Dumitru Orăşeanu   +4 more
doaj   +1 more source

Reabilitarea postchirurgicală a copiilor cu leziuni tumorale ale regiunii maxilo-faciale

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2021
Introducere. Tumorile la copii prezintă o temă specifică și permanent actuală. Odată cu apariția noilor tehnologii de diagnostic se constată o incidență crescândă a tumorilor la copii.
Silvia Railean, Cristina Postam, Gheorghe Granciuc, Volovei Marcel   +3 more
doaj   +1 more source

PROFILAXIA CU PALIVIZUMAB LA SUGARII CU MALFORMAŢII CARDIACE CONGENITALE [PDF]

Romanian Journal of Pediatrics, 2013
Introducere. Infecţiile respiratorii cauzate de virusul sinciţial respirator la copiii cu malformaţii cardiace congenitale reprezintă o importantă cauză de decompensare, care determină spitalizări repetate, cu durată prelungită.
Amalia Făgărăşan, Carmen Şuteu, Iolanda Muntean, Liliana Gozar, Sorina Paşc, Borka-Balás Réka, Rodica Togănel   +6 more
doaj   +1 more source

SINDROMUL METABOLIC LA COPII: FACTORI DE RISC, PARTICULARITĂȚI DE DIAGNOSTIC ȘI TRATAMENT

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2023
Introducere: Prevalența sindromului metabolic la copii este în creștere, în paralel cu tendințele crescânde ale ratelor de obezitate, acest fapt impune necesitatea unui diagnostic cât mai precoce al factorilor de risc prin utilizarea unor biomarkeri non ...
Svetlana COJOCARI, Nelea MĂTRĂGUNĂ, Lilia BICHIR-THOREAC   +2 more
doaj   +1 more source