Results 21 to 30 of about 46,242,060 (244)

In vivo behavior of [64Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer

open access: yesFrontiers in Medicine, 2022
To overcome resistance to chemotherapy for colorectal cancer, we propose to validate in vivo a novel terpyridine-platinum (TP) compound radiolabeled with the radio-theranostic isotope 64Cu.
Meysam Khosravifarsani   +5 more
doaj   +1 more source

Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers

open access: yesEJNMMI Research, 2017
Background In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is ...
M.A. Avila-Rodriguez   +9 more
doaj   +1 more source

Preparation and Evaluation of 64Cu-Radiolabled Dual-Ligand Multifunctional Gold Nanoparticles for Tumor Theragnosis

open access: yesPharmaceuticals, 2023
Gold nanoparticles (AuNPs) are cutting-edge platforms for combined diagnostic and therapeutic approaches due to their exquisite physicochemical and optical properties. Using the AuNPs physically produced by femtosecond pulsed laser ablation of bulk Au in
Karim Mhanna   +11 more
doaj   +1 more source

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make

open access: yesMolecules, 2022
A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied.
Bayirta V. Egorova   +9 more
doaj   +1 more source

Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH

open access: yesBiosensors, 2022
Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are few methods for non-invasively measuring tumor extracellular pH, and none are routinely used in ...
Alyssa C. Pollard   +6 more
doaj   +1 more source

Copper Nanoparticles Prepared fromOxalic Precursors [PDF]

open access: yes, 2011
The synthesis of nanoparticles of copper metal via a soft chemistry route is presented in this paper. The method is based on the thermal decomposition under nitrogen or hydrogen of oxalic precursors with a well-controlled morphology and particle size ...
Philippe Tailhades   +5 more
core   +1 more source

Cross-Section Calculations of Medical Radioisotope 64Cu via some Proton, Neutron and Deuteron Reactions

open access: yesCumhuriyet Science Journal, 2023
The Copper-64 radioisotope, whose academic research continues on diagnostic and therapeutic use, was examined in this study. 64Cu radioisotope is unique among other Cu isotopes for medical usage due to its low positron energy, appropriate half-life, and ...
Abdullah Kaplan, Tuğçe Gülümser
doaj   +1 more source

Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the 64Cu-Labelling of Immunoconjugates

open access: yesMolecules, 2022
The development of 64Cu-based immuno-PET radiotracers requires the use of copper-specific bifunctional chelators (BFCs) that contain functional groups allowing both convenient bioconjugation and stable copper complexes to limit in vivo bioreduction ...
Aurélie Maisonial-Besset   +12 more
doaj   +1 more source

Iron, copper, zinc, magnesium, and calcium in postmortem brain tissue from schizophrenic patients [PDF]

open access: yes, 1994
The regional distribution of iron, copper, zinc, magnesium, and calcium in postmortem brain of schizophrenic patients was compared with that of matched controls.
Kruzik, P.   +6 more
core   +1 more source

Cellular lethal damage of 64Cu incorporated in mammalian genome evaluated with Monte Carlo methods

open access: yesFrontiers in Medicine, 2023
PurposeTargeted Radionuclide Therapy (TRT) with Auger Emitters (AE) is a technique that allows targeting specific sites on tumor cells using radionuclides. The toxicity of AE is critically dependent on its proximity to the DNA.
Jhonatan Carrasco-Hernandez   +3 more
doaj   +1 more source

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