Results 51 to 60 of about 46,242,060 (244)

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

The thermodynamic chemistry of the aqueous copper-ammonia thiosulfate system [PDF]

, 2006
A fundamental thermodynamic study was undertaken in order to establish the speciation of copper(I) and copper(II) during the leaching and recovery of gold from thiosulfate-copper-ammonia solutions. Despite considerable research into this complex leaching
Black, Silvia Beatriz
core  

Preclinical Theranostic Profiling of [⁶⁴Cu]Cu-Acetate in Prostate Cancer

Molecules
Copper plays a critical role in cancer biology, with tumor cells exhibiting abnormal copper metabolism that drives proliferation and tumor growth. A limited number of preclinical and clinical studies have reported promising theranostic potential of ...
Sadaf Ghanaatgar Kasbi, Martin Savard, Céléna Dubuc, Yves Dory, Brigitte Guérin, Fernand Gobeil   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Copper-NHC complexes in catalysis [PDF]

, 2015
The authors gratefully acknowledge the Royal Society (University Research Fellowship to C.S.J.C.) for funding.Although the chemistry of copper has a long history [1a-d], the relatively recent discovery of N-heterocyclic carbene (NHC) as transition-metal ...
Cazin, Catherine, Nahra, Fady, Cazin, Catherine S.J., Lazreg, Faima   +3 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Copper-infused fabric dampen inflammatory gene expression.

, 2023
(a) THP-1 human monocytic cells were differentiated into macrophages following incubation with 100 nM PMA overnight. Cells were then treated with 20 μM of copper(II) chloride dihydrate (CuCl2) or incubated with 100% leachate from copper-infused fabric ...
Khalil P. Chamoun (16993246), Yitian Tang (9395553), Gary Sweeney (332599), Khang Nguyen (12482510), Safoura Zangiabadi (16993243), Ali A. Abdul-Sater (6623273)   +5 more
core   +2 more sources

Synthesis of Bispidine-Based Prostate-Specific Membrane Antigen-Targeted Conjugate and Initial Investigations

Organics
Nowadays, PSMA ligands are widely used for radiotheragnostic purposes in prostate cancer. The synthesis of a PSMA-Bisp conjugate was developed and realized with good yield (overall yield ~58% for the last two steps).
Aleksei E. Machulkin, Stanislav A. Petrov, Maria D. Kraynova, Anastasiia S. Garanina, Bayirta V. Egorova, Roman V. Timoshenko, Alexander N. Vaneev, Alexander S. Erofeev, Anna B. Priselkova, Mikhail A. Kalinin, Aleksei V. Medved′ko, Stepan N. Kalmykov, Elena K. Beloglazkina, Sergey Z. Vatsadze   +13 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]

, 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W, Rae, Colin, Boyd, Marie, Sorensen, Annette, Mairs, Robert J., Tesson, M.   +5 more
core   +3 more sources