Results 1 to 10 of about 5,554 (152)

Activity and Trafficking of Copper-Transporting ATPases in Tumor Development and Defense against Platinum-Based Drugs [PDF]

Cells, 2019
Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular processes. One of these is the maintenance of copper (Cu) homeostasis operated by the Golgi-localized Cu-transporting ATPases ATP7A and ATP7B.
Raffaella Petruzzelli, Roman S. Polishchuk   +1 more
doaj   +4 more sources

Gene Expression Analysis of Three Putative Copper-Transporting ATPases in Copper-Tolerant Fibroporia radiculosa [PDF]

Frontiers in Microbiology, 2020
Copper tolerance of brown-rot basidiomycete decay fungi can lessen the efficacy of copper-containing wood preservatives for wood products in-service. The purpose of this study was to evaluate wood mass loss and differential expression of three genes that
Katie M. Ohno, Amy B. Bishell, Glen R. Stanosz   +2 more
doaj   +4 more sources

Structural basis of ion uptake in copper-transporting P1B-type ATPases [PDF]

Nature Communications, 2022
P1B-type ATPases export excess transition metals from cells. Here, the authors report a molecular structure of CopA, a coppertransporting P1B-ATPase from A. fulgidus, in an inward-facing E1 conformation.
Nina Salustros, Christina Grønberg, Nisansala S. Abeyrathna, Pin Lyu, Fredrik Orädd, Kaituo Wang, Magnus Andersson, Gabriele Meloni, Pontus Gourdon   +8 more
doaj   +2 more sources

IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations [PDF]

Frontiers in Neurology
IDEDNIK syndrome (formerly MEDNIK syndrome, OMIM #609313) is a rare autosomal recessive neurocutaneous disorder characterized by dysregulated copper metabolism and multisystem involvement. The primary causative gene, AP1S1, encodes the σ1A subunit of the
Rong Wu, Xingguang Luo, Xiao-Ping Wang
doaj   +2 more sources

Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases [PDF]

Nature Communications
Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood.
Zongxin Guo, Fredrik Orädd, Viktoria Bågenholm, Christina Grønberg, Jian Feng Ma, Peter Ott, Yong Wang, Magnus Andersson, Per Amstrup Pedersen, Kaituo Wang, Pontus Gourdon   +10 more
doaj   +2 more sources

The Plasma Membrane P-Type ATPase CtpA Is Required for Mycobacterium tuberculosis Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis [PDF]

Biomedicines
Background/Objective: Finding new targets to attenuate Mycobacterium tuberculosis (Mtb) is key in the development of new TB vaccines. In this context, plasma membrane P-type ATPases are relevant for mycobacterial homeostasis and virulence.
Marcela López-Ruíz, Jorge Barrios-Payán, Milena Maya-Hoyos, Rogelio Hernández-Pando, Marisol Ocampo, Carlos Y. Soto, Dulce Mata-Espinosa   +6 more
doaj   +2 more sources

Functional Analysis of FoCrpA in Fusarium oxysporum Causing Rice Seedling Blight [PDF]

Journal of Fungi
Fusarium oxysporum is one of the main pathogens causing rice seedling blight disease. Revealing its pathogenic mechanism is of great significance for formulating prevention and control strategies for rice seedling blight disease.
Chun Wang, Liang Wang, Xuanjie Zhao, Lei Hou, Qingran Liu, Rui Ren, Anqi Lv, Xinyang Liu, Tianliang Xiong, Peng Guo, Xiaofeng Xu, Zhe Ni, Chunlai Liu, Junhua Zhang   +13 more
doaj   +2 more sources

ATPase copper transporting beta attenuates malignant features with high expression as an indicator of favorable prognosis in breast cancer. [PDF]

Breast Cancer
Soeda I, Shibata M, Inaishi T, Ichikawa T, Sugino K, Kanaya E, Kanda M, Hayashi M, Masuda N.   +8 more
europepmc   +3 more sources

The implications and prospect of cuproptosis-related genes and copper transporters in cancer progression

Frontiers in Oncology, 2023
Currently, cancer has become one of the major public health problems worldwide. Apoptosis is an important anti-cancer defense mechanism, which is used in the development of targeted drugs.
Qianwen Zhao, Tonggang Qi
doaj   +1 more source

Sensitization of cancer cells towards Cisplatin and Carboplatin by protein kinase D inhibitors through modulation of ATP7A/B (copper transport ATPases)

Cancer Treatment and Research Communications, 2022
Drug resistance of cancer cells is a significant impediment to effective chemotherapy. One primary reason for this is copper exporters - ATPase copper transporting alpha (ATP7A) and ATPase copper transporting beta (ATP7B). These molecular pumps belong to
Prajit Janardhanan, Aswathi Kodenchery Somasundaran, Anjali Jayasree Balakrishnan, Rajendra Pilankatta   +3 more
doaj   +1 more source