Results 131 to 140 of about 2,527 (168)

Copper Dyshomeostasis, Redox Buffering and Immune Aging Converge on Cuproptosis in Age-Related Diseases. [PDF]

Antioxidants (Basel)
Jin Y, Lu K, Yang Y.
europepmc   +1 more source

Strategies to combat cancer drug resistance: focus on copper metabolism and cuproptosis. [PDF]

Cancer Drug Resist
Yao L, Jiang B, Xu D.
europepmc   +1 more source

Copper homeostasis and cuproptosis: implications for neurodegenerative diseases. [PDF]

Front Aging Neurosci
Tao F, Lin M, Meng X, Huang L, Zhuo B, Jiang S, Deng S, Meng Z, Shi J.   +8 more
europepmc   +1 more source

Copper Dyshomeostasis Affects α-Synuclein Clearance Mechanisms in Parkinson's Disease: Insights from In Vitro Models and Translational Evidence. [PDF]

Int J Mol Sci
Musarò D, Greco M, Lanza M, Damato M, Maffia M.   +4 more
europepmc   +1 more source

Novel and less invasive biomarker assays to measure liver ATP7B in Wilson disease patients. [PDF]

Sci Rep
Jiang RJ, Chen L, Amburgey K, La DPM, Fischbacher B, Holgersen EM, Ronco L, Gehring AJ, Feld JJ, Cheung-Ong K.   +9 more
europepmc   +1 more source

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Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins

Journal of Bioenergetics and Biomembranes, 2007
Copper plays an essential role in human physiology and is indispensable for normal growth and development. Enzymes that are involved in connective tissue formation, neurotransmitter biosynthesis, iron transport, and others essential physiological processes require copper as a cofactor to mediate their reactions. The biosynthetic incorporation of copper
Rachel, Linz, Svetlana, Lutsenko
openaire   +4 more sources

Insights into the mechanism of copper transport by the Wilson and Menkes disease copper-transporting ATPases

Inorganica Chimica Acta, 2002
Menkes and Wilson diseases are two closely related hereditary disorders of copper metabolism. The genes for these disorders have been cloned and identified as copper-transporting ATPases, which are members of a large family of cation transporters, the P-type ATPases.
Negah Fatemi, Bibudhendra Sarkar
openaire   +3 more sources

Structural and Functional Insights of Wilson Disease Copper-Transporting ATPase

Journal of Bioenergetics and Biomembranes, 2002
Wilson disease is an autosomal recessive disorder of copper metabolism. The gene for this disorder has been cloned and identified to encode a copper-transporting ATPase (ATP7B), a member of a large family of cation transporters, the P-type ATPases. In addition to the core elements common to all P-type ATPases, the Wilson copper-transporting ATPase has ...
Negah, Fatemi, Bibudhendra, Sarkar
openaire   +2 more sources

Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport

Journal of the American Chemical Society, 2017
Cu-ATPases are membrane copper transporters present in all kingdoms of life. They play a central role in Cu homeostasis by pumping Cu ions across cell membranes with energy derived from ATP hydrolysis. In this work, the Cu-ATPase CopA from Escherichia coli was expressed and purified in fully functional form and demonstrated to bind Cu(I) with ...
Chathuri J. K. Wijekoon, Saumya R. Udagedara, Roland L. Knorr, Rumiana Dimova, Anthony G. Wedd, Zhiguang Xiao   +5 more
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The Copper-Transporting ATpase Defective in Wilson Disease

1999
Two critical genes have been recognized as essential for the export of copper from cells. The proteins encoded by these genes are very similar, yet perform different functions. Between them, they play a role in controlling copper levels in cells, providing for copper essential for number of enzymes, while preventing the accumulation of toxic levels of ...
Diane W. Cox, John R. Forbes, Manoj S. Nanji   +2 more
openaire   +1 more source