Results 141 to 150 of about 2,574 (179)

From molecular crosstalk to precision therapy: targeting ferroptosis and cuproptosis in oral squamous cell carcinoma. [PDF]

Front Oncol
Ma X, Chen Y, Mai H, Lai P, Alimujiang A, Lu M.   +5 more
europepmc   +1 more source

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Function and Regulation of Human Copper-Transporting ATPases

Physiological Reviews, 2007
Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily conserved polytopic membrane proteins with essential roles in human physiology. The Cu-ATPases are expressed in most tissues, and their transport activity is crucial for central nervous system development, liver function, connective tissue formation, and many other ...
Svetlana Lutsenko, Oleg Y Dmitriev
exaly   +3 more sources

Insights into the mechanism of copper transport by the Wilson and Menkes disease copper-transporting ATPases

Inorganica Chimica Acta, 2002
Menkes and Wilson diseases are two closely related hereditary disorders of copper metabolism. The genes for these disorders have been cloned and identified as copper-transporting ATPases, which are members of a large family of cation transporters, the P-type ATPases.
Bibudhendra Sarkar
exaly   +2 more sources

Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins

Journal of Bioenergetics and Biomembranes, 2007
Copper plays an essential role in human physiology and is indispensable for normal growth and development. Enzymes that are involved in connective tissue formation, neurotransmitter biosynthesis, iron transport, and others essential physiological processes require copper as a cofactor to mediate their reactions. The biosynthetic incorporation of copper
Svetlana Lutsenko, Lutsenko Svetlana
exaly   +3 more sources

Phylogenetic analysis of heavy-metal ATPases in fungi and characterization of the copper-transporting ATPase of Cochliobolus heterostrophus

Mycological Research, 2009
We performed a phylogenetic analysis of heavy-metal ATPases (HMAs) in fungi and found that HMAs can be divided into three groups, A, B, and C. Group A is predicted to deliver copper ions to copper-containing proteins, while Groups B and C are thought to function as cell-membrane copper-efflux pumps.
Yoshimoto Saitoh, Kosuke Izumitsu, Chihiro Tanaka   +2 more
exaly   +3 more sources

The Copper Transporting Atpases in Human Disease

2002
Jonathan D Gitlin, Gitlin Jonathan D
exaly   +2 more sources

Copper Transporting P-Type ATPases and Human Disease

Journal of Bioenergetics and Biomembranes, 2002
Copper transporting P-type ATPases, designated ATP7A and ATP7B, play an essential role in mammalian copper balance. Impaired intestinal transport of copper, resulting from mutations in the ATP7A gene, lead to Menkes disease in humans. Defects in a similar gene, the copper transporting ATPase ATP7B, result in Wilson disease.
Diane W, Cox, Steven D P, Moore
openaire   +2 more sources

Structural and Functional Insights of Wilson Disease Copper-Transporting ATPase

Journal of Bioenergetics and Biomembranes, 2002
Wilson disease is an autosomal recessive disorder of copper metabolism. The gene for this disorder has been cloned and identified to encode a copper-transporting ATPase (ATP7B), a member of a large family of cation transporters, the P-type ATPases. In addition to the core elements common to all P-type ATPases, the Wilson copper-transporting ATPase has ...
Negah, Fatemi, Bibudhendra, Sarkar
openaire   +2 more sources

Conservation of copper-transporting P(IB)-type ATPase function

BioMetals, 2010
Copper-transporting P(IB)-type ATPases are highly conserved, and while unicellular eukaryotes and invertebrates have only one, a gene duplication has occurred during vertebrate evolution. Copper-induced trafficking of mammalian ATP7A and ATP7B from the trans-Golgi Network towards the plasma membrane is critical for their role in copper homeostasis.
Southon, Adam, Palstra, Nickless, Veldhuis, Nicholas, Gaeth, Ann, Robin, Charles, Burke, Richard, Camakaris, James   +6 more
openaire   +5 more sources