Results 151 to 160 of about 2,574 (179)

A copper-transporting ATPase BcCCC2 is necessary for pathogenicity of Botrytis cinerea

Molecular Genetics and Genomics, 2010
Copper is an essential trace element that serves as a cofactor for numerous enzymes. In eukaryotes, copper-transporting ATPases deliver copper to various copper-containing proteins in the trans-golgi network. This study identified a copper-transporting ATPase gene BcCcc2 in a fungus pathogenic to plants, Botrytis cinerea. We investigated the biological
Yoshimoto, Saitoh, Kosuke, Izumitsu, Atsushi, Morita, Chihiro, Tanaka   +3 more
openaire   +2 more sources

The Copper-Transporting ATpase Defective in Wilson Disease

1999
Two critical genes have been recognized as essential for the export of copper from cells. The proteins encoded by these genes are very similar, yet perform different functions. Between them, they play a role in controlling copper levels in cells, providing for copper essential for number of enzymes, while preventing the accumulation of toxic levels of ...
Diane W. Cox, John R. Forbes, Manoj S. Nanji   +2 more
openaire   +1 more source

Expression and Localization of Menkes and Wilson Copper Transporting ATPases in Human Placenta

Placenta, 2004
Copper is an essential trace element necessary for normal growth and development. During pregnancy, copper is transported from the maternal circulation to the fetus by mechanisms which have not been clearly elucidated. Two copper transporting ATPases, Menkes (ATP7A; MNK) and Wilson (ATP7B; WND) are known to be expressed in the placenta and are thought ...
B, Hardman, U, Manuelpillai, E M, Wallace, S, van de Waasenburg, M, Cater, J F B, Mercer, M L, Ackland   +6 more
openaire   +2 more sources

Identification of a copper-transporting ATPase involved in biosynthesis of A. flavus conidial pigment

Applied Microbiology and Biotechnology, 2019
Conidia are asexual spores and play a crucial role in fungal dissemination. Conidial pigmentation is important for tolerance against UV radiation and contributes to survival of fungi. The molecular basis of conidial pigmentation has been studied in several fungal species.
Perng-Kuang, Chang, Leslie L, Scharfenstein, Brian, Mack, Qijian, Wei, Matthew, Gilbert, Matthew, Lebar, Jeffrey W, Cary   +6 more
openaire   +2 more sources

Copper Does Not Alter the Intracellular Distribution of ATP7B, a Copper-Transporting ATPase

Biochemical and Biophysical Research Communications, 2000
Wilson's disease is a genetic disorder characterized by the accumulation of copper in the body due to a defect of biliary copper excretion. However, the mechanism of biliary copper excretion has not been fully clarified. We examined the effect of copper on the intracellular localization of the Wilson disease gene product (ATP7B) and green fluorescent ...
M, Harada, S, Sakisaka, T, Kawaguchi, R, Kimura, E, Taniguchi, H, Koga, S, Hanada, S, Baba, K, Furuta, R, Kumashiro, T, Sugiyama, M, Sata   +11 more
openaire   +2 more sources

[Identification of a fragment of ceruloplasmin, interacting with copper-transporting Menkes ATPase].

Bioorganicheskaia khimiia, 2000
The interaction was studied of ceruloplasmin (Cp, EC 1.16.3.1), a copper-containing plasma protein, with two synthetic peptides P15 and P16 whose structures correlate with those of the noncytosolic regions of the copper transfer P1 type ATPase (ATP7A), apparently encoded by the Menkes disease gene (Atp7a).
N V, Tsymbalenko, N A, Platonova, L V, Puchkova, S V, Mokshina, L K, Sasina, N N, Skvortsova, B S, Mishchenko, Ts A, Egorov, V S, Gaĭtskoki   +8 more
openaire   +2 more sources

Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport

Journal of the American Chemical Society, 2017
Cu-ATPases are membrane copper transporters present in all kingdoms of life. They play a central role in Cu homeostasis by pumping Cu ions across cell membranes with energy derived from ATP hydrolysis. In this work, the Cu-ATPase CopA from Escherichia coli was expressed and purified in fully functional form and demonstrated to bind Cu(I) with ...
Chathuri J. K. Wijekoon, Saumya R. Udagedara, Roland L. Knorr, Rumiana Dimova, Anthony G. Wedd, Zhiguang Xiao   +5 more
openaire   +4 more sources

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

Nature Genetics, 1993
Wilson disease (WD) is an autosomal recessive disorder characterized by the toxic accumulation of copper in a number of organs, particularly the liver and brain. As shown in the accompanying paper, linkage disequilibrium & haplotype analysis confirmed the disease locus to a single marker interval at 13q14.3.
R. E. Tanzi, K. Petrukhin, I. Chernov, J. L. Pellequer, W. Wasco, B. Ross, D. M. Romano, E. Parano, L. Pavone, L. M. Brzustowicz, DEVOTO, MARCELLA, J. Peppercorn, A. I. Bush, I. Sterlieb, M. Pirastu, J. F. Gusella, O. Evgrafov, G. K. Penchaszadeh, B. Honig, I. S. Edelman, M. B. Soares, I. H. Scheinberg, T. C. Gilliam   +22 more
openaire   +3 more sources

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

Nature Genetics, 1993
Menkes disease is an X-linked disorder of copper transport characterized by progressive neurological degeneration and death in early childhood. We have isolated a candidate gene (Mc1) for Menkes disease and find qualitative or quantitative abnormalities in the mRNA in sixteen of twenty-one Menkes patients.
C, Vulpe, B, Levinson, S, Whitney, S, Packman, J, Gitschier   +4 more
openaire   +2 more sources

Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level

BioMetals, 2007
Copper-transporting ATPase ATP7B (Wilson disease protein) is a member of the P-type ATPase family with characteristic domain structure and distinct ATP-binding site. ATP7B plays a central role in the regulation of copper homeostasis in the liver by delivering copper to the secretory pathway and mediating export of excess copper into the bile.
Mee Y, Bartee, Svetlana, Lutsenko
openaire   +2 more sources