Results 11 to 20 of about 5,675 (258)
Copper-transporting ATPase is important for malaria parasite fertility [PDF]
Molecular Microbiology, 2013 Homeostasis of the trace element copper is essential to all eukaryotic life. Copper serves as a cofactor in metalloenzymes and catalyses electron transfer reactions as well as the generation of potentially toxic reactive oxygen species. Here, we describe
Kenthirapalan, Sanketha +3 more
core +11 more sources
Evolution of copper transporting ATPases in eukaryotic organisms. [PDF]
Curr Genomics, 2012 Copper is an essential nutrient for most life forms, however in excess it can be harmful. The ATP-driven copper pumps (Copper-ATPases) play critical role in living organisms by maintaining appropriate copper levels in cells and tissues. These evolutionary conserved polytopic membrane proteins are present in all phyla from simplest life forms (bacteria)
Gupta A, Lutsenko S.
europepmc +4 more sources
The Release Pathway of Copper Transporting Ptype ATPases [PDF]
Biophysical Journal, 2013 Cellular levels of heavy metals are carefully regulated by the PIB class of P-type ATPases in all kingdoms of life and mutations of the human members ATP7A and ATP7B are the cause of the severe Menkes' and Wilson's diseases. Recently, a crystal structure of a homologous Cu+ ATPase from Legionella pneumophila (LpCopA), trapped in a transition state of ...
Magnus Andersson +5 more
openalex +3 more sources
Essential Cys-Pro-Cys Motif ofCaenorhabditis elegansCopper Transport ATPase [PDF]
Bioscience, Biotechnology, and Biochemistry, 1998 Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast delta ccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast delta ccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is ...
Takao Yoshimizu +4 more
openalex +4 more sources
Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport [PDF]
Biophysical Journal, 2016 Cu+-specific P-type ATPase membrane protein transporters regulate cellular copper levels. The lack of crystal structures in Cu+-binding states has limited our understanding of how ion entry and binding are achieved. Here, we characterize the molecular basis of Cu+ entry using molecular-dynamics simulations, structural modeling, and in vitro and in vivo
Christina Grønberg +4 more
openalex +8 more sources
Biochemical basis of regulation of human copper-transporting ATPases. [PDF]
Arch Biochem Biophys, 2007 Copper is essential for cell metabolism as a cofactor of key metabolic enzymes. The biosynthetic incorporation of copper into secreted and plasma membrane-bound proteins requires activity of the copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B.
Lutsenko S, LeShane ES, Shinde U.
europepmc +4 more sources
Host and Pathogen Copper-Transporting P-Type ATPases Function Antagonistically during Salmonella Infection [PDF]
Infection and Immunity, 2017 ABSTRACT Copper is an essential yet potentially toxic trace element that is required by all aerobic organisms. A key regulator of copper homeostasis in mammalian cells is the copper-transporting P-type ATPase ATP7A, which mediates copper transport from the cytoplasm into the secretory pathway, as well as copper export across the ...
Erik Ladomersky +6 more
openalex +4 more sources
Copper-transporting P-type ATPases use a unique ion-release pathway [PDF]
Nature Structural & Molecular Biology, 2013 Heavy metals in cells are typically regulated by PIB-type ATPases. The first structure of the class, a Cu(+)-ATPase from Legionella pneumophila (LpCopA), outlined a copper transport pathway across the membrane, which was inferred to be occluded. Here we show by molecular dynamics simulations that extracellular water solvated the transmembrane (TM ...
Magnus Andersson +8 more
openalex +7 more sources
PAA1, a P-Type ATPase of Arabidopsis, Functions in Copper Transport in Chloroplasts [PDF]
The Plant Cell, 2003 Copper (Cu) is an essential trace element with important roles as a cofactor in many plant functions, including photosynthesis. However, free Cu ions can cause toxicity, necessitating precise Cu delivery systems. Relatively little is known about Cu transport in plant cells, and no components of the Cu transport machinery in chloroplasts have been ...
Toshiharu Shikanai +4 more
openalex +4 more sources
Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) delivers Cu via the Cu chaperone Atox1 (antioxidant 1) to secretory Cu enzymes, such as lysyl oxidase, and excludes excess Cu.
Varadarajan, Sudhahar +15 more
openaire +2 more sources