Results 101 to 110 of about 1,007,592 (239)

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Relevance of animal models for understanding mammalian copper homeostasis

, 2008
As a trace element, copper has a crucial role in mammalian metabolism, but it can be toxic in excess. The importance of a balanced copper homeostasis is illustrated by several copper-associated disorders in man, such as Menkes and Wilson disease, and in ...
Wijmenga, Cisca; id_orcid, van de Sluis, Bart; id_orcid, Vonk, Willianne I. M.   +2 more
core   +1 more source

Chaperone-derived Cu(I)-binding peptide nanofibers disrupt copper homeostasis in cancer cells [PDF]

Copper (Cu) is a transition metal that plays crucial roles in cellular metabolism. Cu+ homeostasis is upregulated in many cancers and contributes to tumorigenesis.
Hendrik R. A., Jonker, David, Ng, Iain, Harley, Robert, Graf, Petri, Turunen, Jianghong, Rao, Julian, Link, Jeena M., Thekkeyil, Jian, Zhang, Ingo, Lieberwirth, Manfred, Wagner, Katharina, Landfester, Luis Andre, Baptista, Tanja, Weil, Liyang, Cui   +14 more
core   +2 more sources

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Investigating the role of copper homeostasis in the nervous system of drosophila melanogaster

, 2017
Copper is an essential trace metal required by multiple processes within the body, such as energy metabolism, neuropeptide maturation and pigmentation. However, excess copper is toxic to the body, and a homeostatic balance must be achieved using a set of
Hwang, Ern Ci Joab (3773665)
core   +1 more source

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Copper Homeostasis is Important for Pathogenesis of Pseudomonas aeruginosa in Caenorhabditis elegans

, 2018
Transition metal homeostasis is important for organisms, as they are both essential for biological processes as well as toxic. The opportunistic parasite Pseudomonas aeruginosa has shown that metal ion homeostasis, specifically copper, may be important ...
Cano, Tristan B.
core   +3 more sources

Identification and characterisation of copper homeostasis genes

, 2010
© 2010 Dr. Adam SouthonCopper is essential for life, yet also potentially toxic in excess. Copper homeostasis is therefore regulated at the cellular, tissue and organismal levels.
SOUTHON, ADAM
core   +1 more source

Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy

Biomarker Research
Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense.
Suhang Zhang, Qibo Huang, Tuo Ji, Qilin Li, Chuanyu Hu   +4 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source