Results 91 to 100 of about 1,007,592 (239)
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Interplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalis [PDF]
, 2015 Artículo de publicación ISISin acceso a texto completoBy integrating the microarray expression data and a global E. faecalis transcriptional network we identified a sub-network activated by zinc and copper.
Low, Marcela +14 more
core +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs
Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley +1 more source
Advanced Science, EarlyView.Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li +21 more
wiley +1 more source
A primer on copper biology in the brain
Neurobiology of DiseaseThis primer aims to expose scientists who study the brain to the field of copper biology. We briefly discuss key copper homeostasis mechanisms and proteins and place these functions in the context of the brain and neurodevelopment.
Alicia R. Lane +3 more
doaj +1 more source
The EuroBiotech Journal, 2019 The Prion Protein (PrP) is mostly known for its role in prion diseases, where its misfolding and aggregation can cause fatal neurodegenerative conditions such as the bovine spongiform encephalopathy and human Creutzfeldt–Jakob disease.
De Riccardis Lidia +8 more
doaj +1 more source
Neuromorphic Devices and Computing for Sensing, Memory, and Control
Advanced Science, EarlyView.This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu +2 more
wiley +1 more source
The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans [PDF]
, 2016 Copper plays key catalytic and regulatory roles in biochemical processes essential for normal growth, development, and health. Defects in copper metabolism cause Menkes and Wilson’s disease, myeloneuropathy, and cardiovascular disease and are associated ...
Jia, Shang +5 more
core
, 2006 This review covers copper homeostasis and its eventual link with copper involvement in different neurological disorders. Copper plays a dual role in producing reactive oxygen species: damaging the cells and eliciting antioxidant activity.
Valensin, Daniela +3 more
core +1 more source