Results 81 to 90 of about 1,007,592 (239)

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Molecular mechanisms of copper homeostasis

, 1999
Copper is an essential trace element which plays a pivotal role in cell physiology as it constitutes a core part of important cuproenzymes. Novel components of copper homeostasis in humans have been identified recently which have been characterised at ...
J Camakaris (13278537), I Voskoboinik (2570842), Julian Mercer (13076475)   +2 more
core  

Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseases

, 2017
Copper is a trace element essential for almost all living organisms, however the level of intracellular copper needs to be tightly regulated. This review explores the existing literature on the role of glutathione in regulating cellular copper ...
Aditya Shukla, Ashima Bhattacharjee, Kaustav Chakraborty   +2 more
core   +1 more source

Mining genomes of marine cyanobacteria for elements of zinc homeostasis [PDF]

, 2012
Zinc is a recognized essential element for the majority of organisms, and is indispensable for the correct function of hundreds of enzymes and thousands of regulatory proteins.
Schmid, Ralf, A. Millard (3584540), Ksibe, Amira Z., Andrew eMillard, James P. Barnett, Amira Z. Ksibe, D. J. Scanlan (7640840), A. Z. Ksibe (7640837), David J. Scanlan, Amira eKsibe, J. P. Barnett (7640834), Barnett, James P., Ralf eSchmid, Scanlan, David J., James P. Barnett, Millard, Andrew D., Blindauer, Claudia A., James P Barnett, R. Schmid (7606553), C. A. Blindauer (7640843), Claudia Andrea Blindauer, Andrew Millard, David J Scanlan, Ralf Schmid   +23 more
core   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Copper in mammals: mechanism of homeostasis and pathophysiology

, 2006
Copper in mammals: mechanism of homeostasis and ...
M Cater (13694599), J Mercer (7836149)
core  

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Role of copper in central nervous system physiology and pathology

Neural Regeneration Research
Copper is a transition metal and an essential element for the organism, as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs, including the central nervous system.
Martina Locatelli, Cinthia Farina
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Polystyrene nanoplastics perturb trophoblastic copper homeostasis with reduced ATP7B expression

Ecotoxicology and Environmental Safety
Background: Polystyrene nanoplastics (PS-NPs) have been detected in human placental and chorionic villous tissues and have been increasingly linked to adverse pregnancy outcomes. However, whether PS-NPs disrupt copper homeostasis in trophoblast cells and
Shuangkai Xu, Zihan Wang, Anqi Zhao, Han Wang, Weiyi Qian, Qiushi Xia, Yuchen Liu, Lingji Gao, Xinyuan Zhao, Yufei Ni, Xiaofang Tan, Jun Yu   +11 more
doaj   +1 more source