Results 71 to 80 of about 1,007,592 (239)

Adipose-derived mesenchymal stem cell exosomes ameliorate copper metabolism dysregulation and reduce cuproptosis caused by liver IRI

Frontiers in Veterinary Science
IntroductionHepatic ischemia reperfusion injury is an important pathological factor leading to complications after hepatectomy and transplantation.
Lei Cao, Lei Cao, Pujun Li, Pujun Li, Yajun Ma, Yajun Ma, Xiangyu Lu, Xiangyu Lu, Yue Wang, Yue Wang, Hongbin Wang, Hongbin Wang, Jiantao Zhang, Jiantao Zhang, Tao Liu, Tao Liu   +15 more
doaj   +1 more source

COPPER AND COPPER-CONTAINING PESTICIDES: METABOLISM, TOXICITY AND OXIDATIVE STRESS

Journal of Vasyl Stefanyk Precarpathian National University, 2015
The purpose of this paper is to provide a brief review of the current knowledge regarding metabolism and toxicity of copper and copper-based pesticides in living organisms.
Viktor Husak
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

Communications Biology
Copper plays a key role in host-pathogen interaction. We find that during Leishmania major infection, the parasite-harboring macrophage regulates its copper homeostasis pathway in a way to facilitate copper-mediated neutralization of the pathogen. Copper-
Rupam Paul, Adrija Chakrabarty, Suman Samanta, Swastika Dey, Raviranjan Pandey, Saptarshi Maji, Aidan T. Pezacki, Christopher J. Chang, Rupak Datta, Arnab Gupta   +9 more
doaj   +1 more source

Copper connections: coordinating transport, sensing and systemic signalling in plants

Quantitative Plant Biology
Copper is an essential micronutrient that plays critical roles in plant metabolism, development and stress responses through its unique redox properties.
Ju-Chen Chia, Tetiana-Olena Zavodna, Hanna Shatokhina, Yana Kavulych, Olena K. Vatamaniuk   +4 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Balancing copper: From redox biology to disease and therapy

Redox Biochemistry and Chemistry
Copper is an essential transition metal that plays a central role in biological redox chemistry due to its ability to cycle between the Cu(I) and Cu(II) oxidation states. This redox flexibility enables copper to function as a catalytic cofactor in a wide
Raviranjan Pandey, Kaustav Chakraborty, Ashima Bhattacharjee, Arnab Gupta   +3 more
doaj   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Recent Advances in the Biomedical Applications of Copper Nanomaterial‐Mediated Cuproptosis

Advanced NanoBiomed Research
Nanomedicine‐induced cancer cell death has become a prominent area of research in the life sciences field in recent years. The concept of cuproptosis was first proposed in 2022. Copper homeostasis in organisms is tightly regulated by protein transporters
Sijia Wu, Qian Wang, Yuhao Li, Baolin Liu, Yuqing Miao   +4 more
doaj   +1 more source

Arabidopsis Adapts to Copper Deficient Conditions via SPL7, a Master Regulator for Copper Homeostasis [PDF]

, 2009
Copper is one of the essential micronutrients for most living organisms. In higher plants, copper is mainly utilized as a cofactor of proteins involved in photosynthesis and scavenging of reactive oxygen species.
Shikanai, Toshiharu, Yamasaki, Hiroaki
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