The interplay between copper metabolism and microbes: in perspective of host copper-dependent ATPases ATP7A/B [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Copper, a vital element in various physiological processes, is transported from the gastrointestinal tract to tissues and cells through diverse copper transporters.
Yixuan Zhou +5 more
doaj +5 more sources
Copper Metabolism of Astrocytes [PDF]
Frontiers in Aging Neuroscience, 2013 This short review will summarize the current knowledge on the uptake, storage and export of copper ions by astrocytes and will address the potential roles of astrocytes in copper homeostasis in the normal and diseased brain.
Ralf eDringen +2 more
doaj +8 more sources
Regulatory roles of copper metabolism and cuproptosis in human cancers [PDF]
Frontiers in Oncology, 2023 Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration and free radical detoxification.
Zhe Wang +8 more
doaj +3 more sources
Copper metabolism and hepatocellular carcinoma: current insights [PDF]
Frontiers in Oncology, 2023 Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis.
Cheng Zhou +6 more
doaj +3 more sources
Targeting copper metabolism: a promising strategy for cancer treatment [PDF]
Frontiers in Pharmacology, 2023 Copper is an essential micronutrient that plays a critical role in many physiological processes. However, excessive copper accumulation in cancer cells has been linked to tumor growth and metastasis.
Ruimin Kong, Guojuan Sun
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COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression [PDF]
BiomedicinesBackground: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells, with extramedullary myeloma (EMM) being an aggressive form involving malignant infiltration beyond the bone marrow. Copper metabolism
Yajun Wang +7 more
doaj +3 more sources
Identification of copper metabolism-related markers in Parkinson’s disease [PDF]
Annals of MedicineObjectives This study aimed to identify key genes related to copper metabolism in Parkinson’s disease (PD), providing insight into their roles in disease progression.Methods Using bioinformatic analyses, the study identified hub genes related to copper ...
Jie Lin +7 more
doaj +4 more sources
IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy [PDF]
Frontiers in Immunology, 2023 IntroductionCopper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer.
Qisheng Luo +12 more
doaj +2 more sources
Copper Metabolism and Cuproptosis in Ovarian Cancer [PDF]
Clinical and Experimental Obstetrics & GynecologyObjectives: This review provides a comprehensive analysis of copper metabolism and cuproptosis in ovarian cancer (OC), evaluating therapeutic strategies targeting copper to improve clinical outcomes.
Yuhong Xu +4 more
doaj +2 more sources
Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities [PDF]
Frontiers in Molecular BiosciencesCopper is a vital trace metal that facilitates cell proliferation, angiogenesis, and tumour spread. The liver is essential for copper metabolism, hence regulating copper levels is crucial for hepatic health.
Ziling Pang
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