Results 11 to 20 of about 2,206,862 (377)

Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer [PDF]

Frontiers in Endocrinology, 2023
BackgroundOvarian cancer (OC) is one of the most common and most malignant gynecological malignancies in gynecology. On the other hand, dysregulation of copper metabolism (CM) is closely associated with tumourigenesis and progression.
Songyun Zhao, Songyun Zhao, Xin Zhang, Feng Gao, Hao Chi, Jinhao Zhang, Zhijia Xia, Chao Cheng, Jinhui Liu   +8 more
doaj   +3 more sources

α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer’s disease [PDF]

Frontiers in Molecular Biosciences
Alzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeostasis,
Sigrid Kirss, Anette Reinapu, Ekaterina Kabin, Julia Smirnova, Vello Tõugu, Peep Palumaa   +5 more
doaj   +2 more sources

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. [PDF]

Nature Communications, 2020
Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper ...
Bao, Shideng, Bulek, Katarzyna, Cai, Gang, Chang, Christopher J, Chen, Xing, Fox, Paul L, Huang, Emina, Jackson, Mark W, Jia, Shang, Kalady, Matthew F, Li, Xiaoxia, Liao, Yun, Pizarro, Theresa T, Sen, Ganes C, Stark, George R, Tang, Fangqiang, Zhao, Junjie   +16 more
core   +2 more sources

Identification of a copper metabolism‐related gene signature for predicting prognosis and immune response in glioma [PDF]

Cancer Medicine, 2023
Background Gliomas are highly refractory intracranial cancers characterized by genetic and transcriptional heterogeneity. However, therapeutic options are limited.
Ling Li, Wenyuan Leng, Junying Chen, Shaoying Li, Bingxi Lei, Huasong Zhang, Huiying Zhao   +6 more
doaj   +2 more sources

The impact of copper on bone metabolism

Journal of Orthopaedic Translation
Copper is an essential trace element for the human body. Abnormalities in copper metabolism can lead to bone defects, mainly by directly affecting the viability of osteoblasts and osteoclasts and their bone remodeling function, or indirectly regulating ...
Zihan Zhang, Huixue Tang, Tingting Du, Di Yang   +3 more
doaj   +2 more sources

Influence of Silver Nanoparticles on the Growth of Ascitic and Solid Ehrlich Adenocarcinoma: Focus on Copper Metabolism [PDF]

Pharmaceutics, 2023
The link between copper metabolism and tumor progression motivated us to use copper chelators for suppression of tumor growth. We assume that silver nanoparticles (AgNPs) can be used for lowering bioavailable copper.
Daria N. Magazenkova, Ekaterina A. Skomorokhova, Mohammad Al Farroukh, Maria S. Zharkova, Zena M. Jassem, Valeria E. Rekina, Olga V. Shamova, Ludmila V. Puchkova, Ekaterina Y. Ilyechova   +8 more
doaj   +2 more sources

Disorders of Copper Metabolism in Children—A Problem too Rarely Recognized [PDF]

Metabolites
Copper plays an important role in metabolic processes. Both deficiency and excess of this element have a negative effect and lead to pathological conditions. Copper is a cofactor of many enzymatic reactions.
Sabina Więcek, Justyna Paprocka
doaj   +2 more sources

α-lipoic acid has the potential to normalize copper metabolism, which is dysregulated in Alzheimer’s disease [PDF]

bioRxiv, 2021
Background: Alzheimer’s disease (AD) is an age-dependent progressive neurodegenerative disorder and the most common cause of dementia. The treatment and prevention of AD present immense yet unmet needs.
Kristel Metsla, Sigrid Kirss, Katrina Laks, Gertrud Sildnik, Mari Palgi, Teele Palumaa, Vello Tõugu, Peep Palumaa   +7 more
openalex   +2 more sources

Mechanisms of copper metabolism and cuproptosis: implications for liver diseases [PDF]

Front Immunol
Chen H, Li D, Zhang H, Zhang M, Lin Y, He H, Liu A, Shen S, Wang Y, Han Z.   +9 more
europepmc   +3 more sources

Copper metabolism in cell death and autophagy. [PDF]

Autophagy, 2023
Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as ...
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X.   +5 more
europepmc   +2 more sources