Results 11 to 20 of about 264,643 (200)

Identification of a copper metabolism‐related gene signature for predicting prognosis and immune response in glioma [PDF]

Cancer Medicine, 2023
Background Gliomas are highly refractory intracranial cancers characterized by genetic and transcriptional heterogeneity. However, therapeutic options are limited.
Ling Li, Wenyuan Leng, Junying Chen, Shaoying Li, Bingxi Lei, Huasong Zhang, Huiying Zhao   +6 more
doaj   +2 more sources

Disorders of Copper Metabolism in Children—A Problem too Rarely Recognized [PDF]

Metabolites
Copper plays an important role in metabolic processes. Both deficiency and excess of this element have a negative effect and lead to pathological conditions. Copper is a cofactor of many enzymatic reactions.
Sabina Więcek, Justyna Paprocka
doaj   +2 more sources

Metabolism of copper and possibilities for its regulation [PDF]

Proceedings of the Estonian Academy of Sciences, 2023
Copper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic.
Peep Palumaa
doaj   +1 more source

Copper metabolism in cell death and autophagy. [PDF]

Autophagy, 2023
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X.   +5 more
europepmc   +2 more sources

Lipid and energy metabolism in Wilson disease

Liver Research, 2020
Copper accumulation and deficiency are reciprocally connected to lipid metabolism. In Wilson disease (WD), which is caused by a genetic loss of function of the copper-transporting P-type ATPase beta, copper accumulates mainly in the liver and lipid ...
Tagreed A. Mazi, Noreene M. Shibata, Valentina Medici   +2 more
doaj   +1 more source

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism

Biomedicines, 2023
Osteonecrosis of the femoral head (ONFH) is a common disabling disease. Copper has positive effects on cells that regulate bone metabolism. However, the relationship between copper metabolism (CM) and steroid-induced ONFH (SONFH) remains unclear.
Baochuang Qi, Chuan Li, Xingbo Cai, Luqiao Pu, Minzheng Guo, Zhifang Tang, Pengfei Bu, Yongqing Xu   +7 more
doaj   +1 more source

Copper metabolism patterns and tumor microenvironment characterization in colon adenocarcinoma

Frontiers in Oncology, 2022
Copper participates in biological processes such as oxygen metabolism and iron uptake, and is a key factor in immune regulation. Based on the transcription data, mutation data and clinical data of colon adenocarcinoma (COAD) patients from The Cancer ...
Jianwei Lin, Bixian Luo, Xinbo Yu, Zheyu Yang, Mingliang Wang, Mingliang Wang, Wei Cai   +6 more
doaj   +1 more source

Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia

Molecular Therapy: Nucleic Acids, 2013
Fetal brain-directed gene addition represents an under-appreciated tool for investigating novel therapeutic approaches in animal models of central nervous system diseases with early prenatal onset.
Marie Reine Haddad, Anthony Donsante, Patricia Zerfas, Stephen G Kaler   +3 more
doaj   +1 more source

Copper-related genes predict prognosis and characteristics of breast cancer

Frontiers in Immunology, 2023
BackgroundThe role of copper in cancer treatment is multifaceted, with copper homeostasis-related genes associated with both breast cancer prognosis and chemotherapy resistance. Interestingly, both elimination and overload of copper have been reported to
Yi Liu, Jiandong Wang, Mengxi Jiang, Mengxi Jiang   +3 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources