Results 31 to 40 of about 2,206,862 (377)

Lipid and energy metabolism in Wilson disease

Liver Research, 2020
Copper accumulation and deficiency are reciprocally connected to lipid metabolism. In Wilson disease (WD), which is caused by a genetic loss of function of the copper-transporting P-type ATPase beta, copper accumulates mainly in the liver and lipid ...
Tagreed A. Mazi, Noreene M. Shibata, Valentina Medici   +2 more
doaj   +1 more source

An Emerging Role of Defective Copper Metabolism in Heart Disease

Nutrients, 2022
Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, iron mobilization, connective tissue ...
Yun Liu, Ji Miao
semanticscholar   +1 more source

Copper metabolism patterns and tumor microenvironment characterization in colon adenocarcinoma

Frontiers in Oncology, 2022
Copper participates in biological processes such as oxygen metabolism and iron uptake, and is a key factor in immune regulation. Based on the transcription data, mutation data and clinical data of colon adenocarcinoma (COAD) patients from The Cancer ...
Jianwei Lin, Bixian Luo, Xinbo Yu, Zheyu Yang, Mingliang Wang, Mingliang Wang, Wei Cai   +6 more
doaj   +1 more source

Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter.

Human Molecular Genetics, 2022
The high-affinity copper transporter CTR1 is encoded by CTR1 (SLC31A1), a gene locus for which no detailed genotype-phenotype correlations have previously been reported.
S. Batzios, Galit Tal, Andrew Distasio, Yanyan Peng, Christiana Charalambous, P. Nicolaides, E. Kamsteeg, S. Korman, H. Mandel, P. Steinbach, Ling Yi, Summer R. Fair, Mark E. Hester, A. Drousiotou, S. Kaler   +14 more
semanticscholar   +1 more source

Copper-related genes predict prognosis and characteristics of breast cancer

Frontiers in Immunology, 2023
BackgroundThe role of copper in cancer treatment is multifaceted, with copper homeostasis-related genes associated with both breast cancer prognosis and chemotherapy resistance. Interestingly, both elimination and overload of copper have been reported to
Yi Liu, Jiandong Wang, Mengxi Jiang, Mengxi Jiang   +3 more
doaj   +1 more source

Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia

Molecular Therapy: Nucleic Acids, 2013
Fetal brain-directed gene addition represents an under-appreciated tool for investigating novel therapeutic approaches in animal models of central nervous system diseases with early prenatal onset.
Marie Reine Haddad, Anthony Donsante, Patricia Zerfas, Stephen G Kaler   +3 more
doaj   +1 more source

Disrupting Cu trafficking as a potential therapy for cancer

Frontiers in Molecular Biosciences, 2022
Copper ions play a crucial role in various cellular biological processes. However, these copper ions can also lead to toxicity when their concentration is not controlled by a sophisticated copper-trafficking system. Copper dys-homeostasis has been linked
Zena Qasem, Matic Pavlin, Matic Pavlin, Ida Ritacco, Ida Ritacco, Matan Y. Avivi, Shelly Meron, Melanie Hirsch, Yulia Shenberger, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein   +11 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation

Metabolites, 2023
Trace metal elements are of vital importance for fundamental biological processes. They function in various metabolic pathways after the long evolution of living organisms.
Zhendong Sun, Yuzhuo Shao, Kunhao Yan, Tianzhao Yao, Lulu Liu, Feifei Sun, Jiarui Wu, Yunpeng Huang   +7 more
semanticscholar   +1 more source

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism

Biomedicines, 2023
Osteonecrosis of the femoral head (ONFH) is a common disabling disease. Copper has positive effects on cells that regulate bone metabolism. However, the relationship between copper metabolism (CM) and steroid-induced ONFH (SONFH) remains unclear.
Baochuang Qi, Chuan Li, Xingbo Cai, Luqiao Pu, Minzheng Guo, Zhifang Tang, Pengfei Bu, Yongqing Xu   +7 more
doaj   +1 more source