Study on the Mechanism of Coptis Chinensis in the Treatment of Diabetic Nephropathy Based on Network Pharmacology [PDF]
BIO Web of Conferences, 2023 To investigate the therapeutic effects of Coptis chinensis on diabetic nephropathy using systematic pharmacological techniques. The TCMSP database was used to search the main components and related targets of Coptis chinensis; the GeneCards and CTD ...
Yu Cheng +5 more
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Discovery of Nine Dipeptidyl Peptidase-4 Inhibitors from Coptis chinensis Using Virtual Screening, Bioactivity Evaluation, and Binding Studies [PDF]
MoleculesThe objective of this study was to identify multiple alkaloids in Coptis chinensis that demonstrate inhibitory activity against DPP-4 and systematically evaluate their activity and binding characteristics.
Zixi Zhao +8 more
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Significant differences in alkaloid content of
Chinese Medicine, 2009 Background The growing popularity of Chinese herbal medicine in the United States has prompted large-scale import of raw herbs from Asia. Many of the Asian herbs have phylogenetically related North American species.
Skeels Matthew +2 more
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康复学报, 2021 ObjectiveTo explore the mechanism of Coptis chinensis in the treatment of type 2 diabetes mellitus based on network pharmacology and molecular docking.MethodsThe active chemical ingredients of Coptis chinensis were screened through the Traditional ...
LIU Huiling +4 more
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PLoS ONE, 2020 Coptidis alkaloids are the primary active components of Coptis chinensis Franch. Clinical and pharmacodynamic studies have confirmed that Coptidis alkaloids have multiple therapeutic effects including anti-inflammatory, antioxidant and antitumor effects,
Jinyu Li +9 more
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Allotetraploidization event of Coptis chinensis shared by all Ranunculales
Horticultural Plant JournalCoptis chinensis Franch., also named Chinese goldthread is a member of Ranunculaceae in the order Ranunculales and represents an important lineage of early eudicots with traditional medicinal value. In our study, by using syntenic analysis combined with phylogenomic analysis of C.
Yan Zhang +17 more
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Isolation and characterization of a novel (S)-canadine synthase gene from Coptis chinensis [PDF]
Electronic Journal of Biotechnology, 2015 Background: Berberine acts primarily as an important active ingredient in Coptis chinensis and has been traditionally applied in clinical treatment. Nevertheless, little information has been released about C.
Yang He +4 more
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Exploring the relaxation effects of Coptis chinensis and berberine on the lower esophageal sphincter: potential strategies for LES motility disorders [PDF]
BMC Complementary Medicine and TherapiesBackground Esophageal achalasia, a primary disorder impacting the lower esophageal sphincter (LES), presents symptoms such as dysphagia, regurgitation, chest pain, and weight loss.
Wen-Harn Koh +7 more
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Transcriptome and Metabolome Analysis of Isoquinoline Alkaloid Biosynthesis of Coptis chinensis in Different Years. [PDF]
Genes (Basel), 2023 Coptis chinensis is a perennial herb of the Ranunculaceae family. The isoquinoline alkaloid is the main active component of C. chinensis, mainly exists in its rhizomes and has high clinical application potential.
Min X, Zhu T, Hu X, Hou C, He J, Liu X.
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Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis. [PDF]
Plant Biotechnol JABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Song J +14 more
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