Results 11 to 20 of about 74,343 (191)
N-Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characterize the progression of neurodegeneration in a mouse model of fatal mitochondrial encephalopathy and to evaluate the therapeutic
Jiménez-Sánchez L +12 more
europepmc +2 more sources
IMP with exceptions over decorated logic [PDF]
Discrete Mathematics & Theoretical Computer Science, 2018 In this paper, we facilitate the reasoning about impure programming languages, by annotating terms with “decorations”that describe what computational (side) effect evaluation of a term may involve.
Burak Ekici
doaj +1 more source
Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings
Antioxidants, 2021 Coenzyme Q (CoQ) is a vital lipophilic molecule that is endogenously synthesized in the mitochondria of each cell. The CoQ biosynthetic pathway is complex and not completely characterized, and it involves at least thirteen catalytic and regulatory ...
Pilar González-García +5 more
doaj +1 more source
Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. [PDF]
PLoS ONE, 2012 Coenzyme Q(10) (CoQ(10)) is a potent lipophilic antioxidant in cell membranes and a carrier of electrons in the mitochondrial respiratory chain. We previously characterized the effects of varying severities of CoQ(10) deficiency on ROS production and ...
Catarina M Quinzii +3 more
doaj +1 more source
Mechanisms and Therapeutic Effects of Benzoquinone Ring Analogs in Primary CoQ Deficiencies
Antioxidants, 2022 Coenzyme Q (CoQ) is a conserved polyprenylated lipid composed of a redox-active benzoquinone ring and a long polyisoprenyl tail that serves as a membrane anchor.
Alba Pesini +2 more
doaj +1 more source
Alternative splicing of coq-2 controls the levels of rhodoquinone in animals
eLife, 2020 Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels.
June H Tan +9 more
doaj +1 more source
Mixing HOL and Coq in Dedukti (Extended Abstract)
, 2015 We use Dedukti as a logical framework for interoperability. We use automated tools to translate different developments made in HOL and in Coq to Dedukti, and we combine them to prove new results.
Assaf, Ali, Cauderlier, Raphaël
core +6 more sources
Antimicrobial Activity and Antibiofilm Potential of Coenzyme Q0 against Salmonella Typhimurium
Foods, 2021 Coenzyme Q0 (CoQ0) has anti-inflammatory and anti-tumor effects; however, the antimicrobial and antibiofilm activities of CoQ0 against Salmonella enterica serovar Typhimurium are unknown.
Zhuokai Yang +8 more
doaj +1 more source
Biosynthesis, Deficiency, and Supplementation of Coenzyme Q
Antioxidants, 2023 Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Carmine Staiano +6 more
doaj +1 more source
Molecules, 2018 In this study, a series of di-O-caffeoylquinic acids (di-COQs) were systematically investigated for their antioxidant and cytoprotective effects towards •OH-damaged bone marrow-derived mesenchymal stem cells (bmMSCs).
Xican Li +7 more
doaj +1 more source