Results 11 to 20 of about 75,676 (211)

BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues. [PDF]

FASEB J
Graphical abstract illustrating the in vitro and in vivo experimental workflow used to compare BPM31510, a nanoliposomal formulation of oxidized CoQ10, with conventional CoQ10. Chemically induced CoQ‐deficient SH‐SY5Y cells, CoQ‐deficient patient fibroblasts, and C57BL/6J mice receiving oral CoQ10 or intraperitoneal BPM31510 were subjected to plasma ...
Aristizabal-Henao JJ, Wessel SR, Stopka SA, Karmacharya S, Van Cura D, Pesini A, Nickerson KR, Grover K, Zavidij O, Ravi A, Mota AL, Rosen KM, Nastke MD, Cox MK, Narain NR, Modur V, Quinzii CM, Gesta S, Kiebish MA.   +18 more
europepmc   +2 more sources

Rational Engineering of Non-Ubiquinone Containing Corynebacterium glutamicum for Enhanced Coenzyme Q₁₀ Production

Metabolites, 2022
Coenzyme Q10 (CoQ10) is a lipid-soluble compound with important physiological functions and is sought after in the food and cosmetic industries owing to its antioxidant properties.
Arthur Burgardt, Ludovic Pelosi, Mahmoud Hajj Chehade, Volker F. Wendisch, Fabien Pierrel   +4 more
doaj   +1 more source

IMP with exceptions over decorated logic [PDF]

Discrete Mathematics & Theoretical Computer Science, 2018
In this paper, we facilitate the reasoning about impure programming languages, by annotating terms with “decorations”that describe what computational (side) effect evaluation of a term may involve.
Burak Ekici
doaj   +1 more source

Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings

Antioxidants, 2021
Coenzyme Q (CoQ) is a vital lipophilic molecule that is endogenously synthesized in the mitochondria of each cell. The CoQ biosynthetic pathway is complex and not completely characterized, and it involves at least thirteen catalytic and regulatory ...
Pilar González-García, Eliana Barriocanal-Casado, María Elena Díaz-Casado, Sergio López-Herrador, Agustín Hidalgo-Gutiérrez, Luis C. López   +5 more
doaj   +1 more source

CoQ imbalance drives reverse electron transport to disrupt liver metabolism. [PDF]

Nature
Goncalves RLS, Wang ZB, Riveros JK, Parlakgül G, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Hui ST, Coll M, Arruda AP, Burgess SC, Graupera I, Hotamışlıgil GS.   +14 more
europepmc   +2 more sources

Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. [PDF]

PLoS ONE, 2012
Coenzyme Q(10) (CoQ(10)) is a potent lipophilic antioxidant in cell membranes and a carrier of electrons in the mitochondrial respiratory chain. We previously characterized the effects of varying severities of CoQ(10) deficiency on ROS production and ...
Catarina M Quinzii, Saba Tadesse, Ali Naini, Michio Hirano   +3 more
doaj   +1 more source

Mechanisms and Therapeutic Effects of Benzoquinone Ring Analogs in Primary CoQ Deficiencies

Antioxidants, 2022
Coenzyme Q (CoQ) is a conserved polyprenylated lipid composed of a redox-active benzoquinone ring and a long polyisoprenyl tail that serves as a membrane anchor.
Alba Pesini, Agustin Hidalgo-Gutierrez, Catarina M. Quinzii   +2 more
doaj   +1 more source

Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

eLife, 2020
Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels.
June H Tan, Margot Lautens, Laura Romanelli-Cedrez, Jianbin Wang, Michael R Schertzberg, Samantha R Reinl, Richard E Davis, Jennifer N Shepherd, Andrew G Fraser, Gustavo Salinas   +9 more
doaj   +1 more source

Biosynthesis, Deficiency, and Supplementation of Coenzyme Q

Antioxidants, 2023
Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Carmine Staiano, Laura García-Corzo, David Mantle, Nadia Turton, Lauren E. Millichap, Gloria Brea-Calvo, Iain Hargreaves   +6 more
doaj   +1 more source

CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Are Associated with Increased Serum Coenzyme Q₁₀ after Long-Term Supplementation in Women

Antioxidants, 2021
Coenzyme Q10 (CoQ10), an essential component for energy production that exhibits antioxidant activity, is considered a health-supporting and antiaging supplement.
Michiyo Takahashi, Mayumi Nagata, Tetsu Kinoshita, Takehiko Kaneko, Toshikazu Suzuki   +4 more
doaj   +1 more source