Results 211 to 220 of about 1,042,655 (286)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

open access: yesBritish Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire   +28 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci   +15 more
wiley   +1 more source

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC)

open access: yesContact Dermatitis, EarlyView.
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
David Pesqué   +31 more
wiley   +1 more source

Polymeric α‐Hairpinin Allergens Induce a Functional Response via a Single Antibody

open access: yes
Allergy, EarlyView.
Gage O. Leighton   +16 more
wiley   +1 more source

Contact Sensitization in Patients With Frontal Fibrosing Alopecia: Patch Test Results With an Extended Baseline Series in Consecutive Patients

open access: yesContact Dermatitis, EarlyView.
Sensitization to propolis, shellac and gallate mix is FFA‐associated, but its relevance is largely unknown. Sensitization to salicylates is frequent and associated with symptoms of intolerance to sun exposure or sunscreens. No significant improvement by allergen avoidance is identified.
María‐Antonia Pastor‐Nieto   +11 more
wiley   +1 more source

The relationship between digital literacy and mental health resilience among college students-based on the mediating role of digital learning. [PDF]

open access: yesFront Psychol
Li X   +12 more
europepmc   +1 more source

Resource effects of COVID‐induced work‐from home: A qualitative study of parental and non‐parental white collar workers in Germany

open access: yesEuropean Management Review, EarlyView.
Abstract Germany is a corporate environment that is sceptical towards digitalization and work‐from‐home, and in which it is customary to separate professional and personal spheres of life. The COVID‐19 pandemic, and ensuing government‐mandated shutdowns, changed all that by inducing extensive work‐from‐home conditions for most of the white collared ...
Jasmin Mahadevan   +3 more
wiley   +1 more source

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