Results 1 to 10 of about 9,839 (199)

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise [PDF]

Scientific Reports
Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline.
Chunfang Cheng, Shasha Zhang, Chong Chen, Yanchun Gong, Kaizhi Ding, Guoyin Li, Wei Jiang, Zhenyu Zhang, Bin He, Zhihong Hu, Yuhua Li, Lihua Yao   +11 more
doaj   +3 more sources

Cordycepin affects Streptococcus mutans biofilm and interferes with its metabolism [PDF]

BMC Oral Health
Background Streptococcus mutans (S. mutans) contributes to caries. The biofilm formed by S. mutans exhibits greater resistance to drugs and host immune defenses than the planktonic form of the bacteria.
Yidan Shao, Wenyan Zhu, Shanshan Liu, Kai Zhang, Yu Sun, Yudong Liu, Tingchi Wen, Yingxue Zou, Qingwei Zheng   +8 more
doaj   +3 more sources

Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis [PDF]

Frontiers in Pharmacology
Pyroptosis, a form of programmed cell death driven by the NLRP3 inflammasome, is a key contributor to inflammation in various diseases. This study aimed to investigate the anti-inflammatory mechanisms of cordycepin, focusing on its role in macrophage ...
Zige Liu, Li Lv, Jiao Wei, Yuli Xie, Mujia Jili, Yian Huang, Rirong Yang, Rirong Yang, Yu Luo   +8 more
doaj   +3 more sources

Mechanism of Activation of AMPK by Cordycepin [PDF]

Cell Chemical Biology, 2020
Cordycepin (3′-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have many beneficial metabolic effects by activating AMP-activated protein kinase (AMPK), but the ...
Douglas J Lamont
exaly   +4 more sources

Molecular Mechanisms of Temperature-Regulated Cordycepin Biosynthesis in Cordyceps militaris [PDF]

Journal of Fungi
Cordycepin is a key active component of Cordyceps militaris, but the molecular mechanism underlying temperature-regulated biosynthesis remains unclear. In this study, Cordyceps militaris strain KN-1 was used as experimental material, with low-temperature
Jiaxing Shao, Ziwei Zhang, Guanhui Liu, Jinsheng Lin, Ziping Zhang, Xuelin Dai, Ning Jiang, Jie Tu   +7 more
doaj   +2 more sources

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi

Molecules, 2019
Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value.
Xiangkai Li
exaly   +3 more sources

Effects of cordycepin on the microglia-overactivation-induced impairments of growth and development of hippocampal cultured neurons. [PDF]

PLoS ONE, 2015
Microglial cells are normally activated in response to brain injury or immunological stimuli to protect central nervous system (CNS). However, over-activation of microglia conversely amplifies the inflammatory effects and mediates cellular degeneration ...
Jie Peng, Ping Wang, Hongshan Ge, Xianqin Qu, Xingliang Jin   +4 more
doaj   +7 more sources

Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission. [PDF]

Drug Des Devel Ther
Objective This study aimed to investigate the mechanisms and specific targets of cordycepin in the treatment of renal fibrosis using a unilateral ischemia-reperfusion (UIR) model.
Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N.   +12 more
europepmc   +2 more sources

Cordycepin Modulates Microglial M2 Polarization Coupled with Mitochondrial Metabolic Reprogramming by Targeting HKII and PDK2

Advanced Science
The microenvironment mediated by the microglia (MG) M1/M2 phenotypic switch plays a decisive role in the neuronal fate and cognitive function of Alzheimer's disease (AD).
Xin Zhong, Mingyan Liu
exaly   +2 more sources

Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in Cordyceps militaris

Antioxidants, 2023
Cordycepin, also known as 3′-deoxyadenosine, is a major active ingredient of Cordyceps militaris with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content.
Ayman Turk, Solip Lee, Sang Won Yeon, Se Hwan Ryu, Yoo Kyong Han, Young Jun Kim, Sung Min Ko, Beom Seok Kim, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee   +10 more
doaj   +2 more sources