Results 11 to 20 of about 9,908 (255)

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models [PDF]

Ibrain
The aggregation of β‐amyloid (Aβ) peptides has been associated with the onset of Alzheimer's disease (AD) by causing neurotoxicity due to oxidative stress and apoptosis.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
doaj   +3 more sources

Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi [PDF]

Molecules, 2019
To clarify the relationship between neutral lipid content and cordycepin accumulation in Cordyceps militaris, mutants were generated from mixed spores of two C. militaris strains with varying cordycepin-producing capacities.
Peng Qin, ZhiYe Wang, DengXue Lu, HongMei Kang, Guang Li, Rui Guo, YuHui Zhao, RongBing Han, Bing Ji, Yang Zeng   +9 more
doaj   +3 more sources

Improved Cordycepin Production by Cordyceps Militaris Using Corn Steep Liquor Hydrolysate as an Alternative Protein Nitrogen Source

Foods
Cordycepin production in the submerged culture of Cordyceps militaris was demonstrated using hydrolyzed corn processing protein by-products, known as corn steep liquor hydrolysate (CSLH), as an alternative nitrogen source.
Ying Chang, Xiaolan Liu, Yan Jiao, Xiqun Zheng   +3 more
doaj   +2 more sources

The role and mechanisms of cordycepin in inhibiting cancer cells [PDF]

Brazilian Journal of Medical and Biological Research
With the escalating incidence and mortality rates of cancer, there is an ever-growing emphasis on the research of anticancer drugs. Cordycepin, the primary nucleoside antibiotic isolated from Cordyceps militaris, has emerged as a remarkable agent for ...
Gong Yu, Jiahua Peng, Lu Li, Wenbin Yu, Bin He, Bin Xie   +5 more
doaj   +2 more sources

Development of cordycepin formulations for preclinical and clinical studies [PDF]

AAPS PharmSciTech, 2017
There is extensive literature on in vivo studies with cordycepin but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in the dosing vehicles used.
A Kondrashov, A Sato, AM Sugar, BS Pan, C Dou, Cecilia Adrower, Chaolong Qin, Cornelia H. de Moor, CR Hind, DF Nickerson, DW Zhang, EA Thackaberry, F Wang, HG Kim, HJ Cho, HP Wei, HS Tuli, HS Tuli, HS Yoo, J Wong, J Yuan, Jong Bong Lee, JV Julian-Ortiz de, JW Jeong, JW Jeong, K Nakamura, K Nakamura, KJ Won, L Ma, MA Cho, ME Rottenberg, N Yoshikawa, Pavel Gershkovich, Peter M. Fischer, PV Turner, PV Turner, R Ikeda, R Skeist, S Patel, S Shin, SF Leu, XX Zhou, XX Zhou, Y Du, Y Sun, YJ Tsai, YR Lee, YY Wong, Z Cheng, Z Hu, Z Tianzhu, ZL Cai   +51 more
core   +5 more sources

Mechanisms of cordycepin in the treatment of pulmonary arterial hypertension in rats based on metabonomics and transcriptomics

Scientific Reports
Pulmonary arterial hypertension (PAH) is a fatal disease featured by high morbidity and mortality. Although Cordycepin is known for its anti-inflammatory, antioxidant and immune-enhancing effects, its role in PAH treatment and the underlying mechanisms ...
Jiangpeng Lin, Riken Chen, Huizhao Liao, Yuzhuo Zhang, Zhenzhen Zheng, Cheng Hong   +5 more
doaj   +2 more sources

Antitumor Mechanism and Therapeutic Potential of Cordycepin Derivatives

Molecules, 2023
Cordycepin has good antitumor activity, but its clinical application is limited due to the easy deamination of N6 in structure. In this study, a large lipolysis group was introduced at the cordycepin N6 to improve the problem, cordycepin derivatives (3a ...
Linlin Cui, Li Zhao, Guanghuan Shen, Dahai Yu, Tian Yuan, Yingyu Zhang, Bo Yang   +6 more
semanticscholar   +4 more sources

Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes

FEBS Open Bio
Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on ...
Kazuya Kusama, Kodai Oka, Yumi Yashiro, Kanoko Yoshida, Hiroaki Miyaoka, Kazuhiro Tamura   +5 more
doaj   +2 more sources

Effect of <i>Cordyceps militaris</i> Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents. [PDF]

Int J Endocrinol
The increasing global prevalence of obesity, exacerbated by factors such as high‐fat diets and reduced physical activity, poses a substantial risk for lifestyle‐related diseases, particularly in postmenopausal women. Premenopausal women initially have a lower incidence of cardiovascular disease than men, but this risk increases after menopause ...
Kusama K, Fujii C, Yoshida K, Yoshie M, Adachi Y, Miyaoka H, Tamura K.   +6 more
europepmc   +2 more sources

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient-Gene-Disease Interaction. [PDF]

Immun Inflamm Dis
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zang Z, Kong Y, Kong Q.
europepmc   +2 more sources