Results 11 to 20 of about 3,479,520 (326)
Impact of homologous recombination on core genome phylogenies [PDF]
BMC Genomics, 2020 Core genome phylogenies are widely used to build the evolutionary history of individual prokaryote species. By using hundreds or thousands of shared genes, these approaches are the gold standard to reconstruct the relationships of large sets of strains ...
Caroline M. Stott, L. Bobay
semanticscholar +4 more sources
Computational analysis of core promoters in the Drosophila genome [PDF]
Genome Biology, 2002 The core promoter, a region of about 100 base-pairs flanking the transcription start site (TSS), serves as the recognition site for the basal transcription apparatus. Drosophila TSSs have generally been mapped by individual experiments; the low number of accurately mapped TSSs has limited analysis of promoter sequence motifs and the training of ...
Uwe Ohler +3 more
openalex +5 more sources
Using Core Genome Alignments To Assign Bacterial Species [PDF]
mSystems, 2018 With the increasing availability of genome sequences, we sought to develop and apply a robust, portable, and high-resolution method for the assignment of genera and species designations that can recapitulate classically defined taxonomic designations ...
M. Chung +3 more
semanticscholar +6 more sources
Analysis of the Core Genome and Pan-Genome of Autotrophic Acetogenic Bacteria [PDF]
Frontiers in Microbiology, 2016 Acetogens are obligate anaerobic bacteria capable of reducing carbon dioxide (CO2) to multicarbon compounds coupled to the oxidation of inorganic substrates, such as hydrogen (H2) or carbon monoxide (CO), via the Wood-Ljungdahl pathway. Owing to the metabolic capability of CO2 fixation, much attention has been focused on understanding the unique ...
Jongoh Shin +3 more
openalex +5 more sources
Rapid Core-Genome Alignment and Visualization for Thousands of Intraspecific Microbial Genomes [PDF]
, 2014 Though many microbial species or clades now have hundreds of sequenced genomes, existing whole-genome alignment methods do not efficiently handle comparisons on this scale. Here we present the Harvest suite of core-genome alignment and visualization tools for quickly analyzing thousands of intraspecific microbial strains.
Todd J. Treangen +3 more
openalex +5 more sources
“Usage a CRISPR/Cas9-based for obtaining knockouts of economically significant cattle genes” [PDF]
E3S Web of Conferences, 2023 An experimental work dealing with the gene modification using the Cas9 RNA-based editing system was performed. Point site-specific breakpoints in gDNA were introduced at the zygote stage by microinjection of spCas9 mRNA protein and guide RNAs into the ...
Bruter A. +5 more
doaj +1 more source
Core and Accessory Genome Analysis of Vibrio mimicus [PDF]
Microorganisms, 2021 Vibrio mimicus is an emerging pathogen, mainly associated with contaminated seafood consumption. However, little is known about its evolution, biodiversity, and pathogenic potential. This study analyzes the pan-, core, and accessory genomes of nine V. mimicus strains.
Iliana Guardiola-Avila +6 more
openaire +6 more sources
Gene editing CRISPR/Cas9 system for producing cows with hypoallergenic milk on the background of a beta-lactoglobulin gene knockout [PDF]
E3S Web of Conferences, 2020 Beta-lactoglobulin is the main allergen of cow’s milk. Modern approaches to reducing the allergenicity of milk require significant costs for its fermentation. An alternative approach could be the creation of productive breeds with a knockout for the gene
Silaeva Yulia Yu. +4 more
doaj +1 more source
Bio-Protocol, 2023 Generation of zebrafish (Danio rerio) models with targeted insertion of epitope tags and point mutations is highly desirable for functional genomics and disease modeling studies.
Blake Carrington, Raman Sood
doaj +1 more source
BMC Genomics, 2021 Background Archival formalin-fixed, paraffin-embedded (FFPE) tissue samples with clinical and histological data are a singularly valuable resource for developing new molecular biomarkers.
Jin Sung Jang +7 more
doaj +1 more source