Results 21 to 30 of about 3,479,520 (326)
Microbiome, 2022 Background The 16S rRNA gene is used extensively in bacterial phylogenetics, in species delineation, and now widely in microbiome studies. However, the gene suffers from intragenomic heterogeneity, and reports of recombination and an unreliable ...
H. Hassler +6 more
semanticscholar +1 more source
Epistasis, core-genome disharmony, and adaptation in recombining bacteria. [PDF]
mBioABSTRACT Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis.
Taylor AJ +22 more
europepmc +9 more sources
Nature Communications, 2022 The laboratory surveillance of bacillary dysentery is based on a standardised Shigella typing scheme that classifies Shigella strains into four serogroups and more than 50 serotypes on the basis of biochemical tests and lipopolysaccharide O-antigen ...
Iman Yassine +12 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Salmonella enterica (S. enterica) is an important foodborne pathogen, causing food poisoning and human infection, and critically threatening food safety and public health.
Shigan Yan +6 more
semanticscholar +1 more source
The cyanobacterial genome core and the origin of photosynthesis [PDF]
Proceedings of the National Academy of Sciences, 2006 Comparative analysis of 15 complete cyanobacterial genome sequences, including “near minimal” genomes of five strains of Prochlorococcus spp., revealed 1,054 protein families [core cyanobacterial clusters of orthologous groups of proteins (core CyOGs)] encoded in at least 14 of them.
Armen Y. Mulkidjanian +11 more
openaire +2 more sources
Core resources for genome analysis
, 2021 The Wellcome Sanger Institute will sequence and assemble tens of thousands of genomes across the next decade through large-scale biodiversity sequencing projects such as Darwin Tree of Life. The projects span the entire tree of eukaryotic life, and the genomes will enable new and unprecedented science.
Muffato, Matthieu, Blaxter, Mark
openaire +2 more sources
Optimisation of the core subset for the APY approximation of genomic relationships [PDF]
Genetics Selection Evolution, 2022 Abstract Background By entering the era of mega-scale genomics, we are facing many computational issues with standard genomic evaluation models due to their dense data structure and cubic computational complexity. Several scalable approaches have been proposed to address this challenge, such as the Algorithm for Proven ...
Ivan Pocrnic +4 more
openaire +4 more sources
Aggregation and disaggregation features of the human proteome
Molecular Systems Biology, 2020 Protein aggregates have negative implications in disease. While reductionist experiments have increased our understanding of aggregation processes, the systemic view in biological context is still limited.
Tomi A Määttä +6 more
doaj +1 more source
Thermal proteome profiling for interrogating protein interactions
Molecular Systems Biology, 2020 Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic ...
André Mateus +7 more
doaj +1 more source
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish
Cells, 2020 The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide ...
Blake Carrington +2 more
doaj +1 more source