Results 21 to 30 of about 4,042,841 (387)

Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies

Microbiome, 2022
Background The 16S rRNA gene is used extensively in bacterial phylogenetics, in species delineation, and now widely in microbiome studies. However, the gene suffers from intragenomic heterogeneity, and reports of recombination and an unreliable ...
H. Hassler, Brett Probert, Carson Moore, Elizabeth Lawson, Richard W. Jackson, Brook T. Russell, V. P. Richards   +6 more
semanticscholar   +1 more source

Core Genome Multilocus Sequence Typing Scheme for Improved Characterization and Epidemiological Surveillance of Pathogenic Brucella

Journal of Clinical Microbiology, 2022
Brucellosis poses a significant burden to human and animal health worldwide. Robust and harmonized molecular epidemiological approaches and population studies that include routine disease screening are needed to efficiently track the origin and spread of
Mostafa Y. Abdel-Glil, P. Thomas, C. Brandt, F. Melzer, Anbazhagan Subbaiyan, P. Chaudhuri, D. Harmsen, K. Jolley, A. Janowicz, G. Garofolo, H. Neubauer, M. W. Pletz   +11 more
semanticscholar   +1 more source

The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest

Nucleic Acids Res., 2022
Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scattered across ...
Damian Szklarczyk, Rebecca Kirsch, Mikaela Koutrouli, Katerina C. Nastou, Farrokh Mehryary, Radja Hachilif, Annika L. Gable, Tao Fang, N. Doncheva, Sampo Pyysalo, P. Bork, L. Jensen, C. V. Mering   +12 more
semanticscholar   +1 more source

Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing

Nature Communications, 2022
The laboratory surveillance of bacillary dysentery is based on a standardised Shigella typing scheme that classifies Shigella strains into four serogroups and more than 50 serotypes on the basis of biochemical tests and lipopolysaccharide O-antigen ...
Iman Yassine, S. Lefèvre, Elisabeth E. Hansen, C. Ruckly, I. Carle, M. Lejay-Collin, Laetitia Fabre, R. Rafei, D. Clermont, M. P. de la Gandara, F. Dabboussi, N. Thomson, F. Weill   +12 more
semanticscholar   +1 more source

Core and Accessory Genome Analysis of Vibrio mimicus [PDF]

Microorganisms, 2021
Vibrio mimicus is an emerging pathogen, mainly associated with contaminated seafood consumption. However, little is known about its evolution, biodiversity, and pathogenic potential. This study analyzes the pan-, core, and accessory genomes of nine V. mimicus strains.
Iliana Guardiola-Avila, Leonor Sánchez-Busó, Evelia Acedo-Félix, Bruno Gomez-Gil, Manuel Zúñiga-Cabrera, Fernando González-Candelas, Lorena Noriega-Orozco   +6 more
openaire   +6 more sources

Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing

Nature Communications, 2022
Mycobacterium abscessus is an emerging multidrug-resistant non-tuberculous mycobacterium that causes a wide spectrum of infections and has caused several local outbreaks worldwide.
M. Diricks, M. Merker, N. Wetzstein, T. Kohl, S. Niemann, F. Maurer   +5 more
semanticscholar   +1 more source

The Neisseria gonorrhoeae Accessory Genome and Its Association with the Core Genome and Antimicrobial Resistance

Microbiology spectrum, 2022
The emergence of antimicrobial resistance (AMR) against third generation cephalosporins in Neisseria gonorrhoeae is a major public health concern, as these are antibiotics of last resort for the effective treatment of gonorrhea.
J. de Korne-Elenbaas, S. Bruisten, A. V. van Dam, M. Maiden, O. Harrison   +4 more
semanticscholar   +1 more source

Super enhancers—Functional cores under the 3D genome [PDF]

Cell Proliferation, 2020
AbstractComplex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three‐dimensional structure of the genome, plays an important role in gene regulation and expression.
Juqing Zhang, Wei Yue, Yaqi Zhou, Mingzhi Liao, Xingqi Chen, Jinlian Hua   +5 more
openaire   +2 more sources

Genome wide analysis of Arabidopsis core promoters [PDF]

BMC Genomics, 2005
Abstract Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation. The DNA elements required for core promoter function in plants are poorly understood.
Molina Carlos, Grotewold Erich
openaire   +3 more sources

Aggregation and disaggregation features of the human proteome

Molecular Systems Biology, 2020
Protein aggregates have negative implications in disease. While reductionist experiments have increased our understanding of aggregation processes, the systemic view in biological context is still limited.
Tomi A Määttä, Mandy Rettel, Sindhuja Sridharan, Dominic Helm, Nils Kurzawa, Frank Stein, Mikhail M Savitski   +6 more
doaj   +1 more source