Results 41 to 50 of about 683,800 (267)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Discussion on the evolution of architecture of the core network of cellular Internet of things

Dianxin kexue, 2023
At present, there are two Internet of things networks facing 2G, 4G, NB-IoT and facing toB core networks.In order to simplify the network, enhance the capability, enhance the benefit, and facilitate the operation and maintenance, it is necessary to ...
Hongyuan MA, Wei ZHOU, Yan FU, Yongping SHAO, Dan LI   +4 more
doaj  

Oxidative Stress-Inducing Anticancer Therapies: Taking a Closer Look at Their Immunomodulating Effects

Antioxidants, 2020
Cancer cells are characterized by higher levels of reactive oxygen species (ROS) compared to normal cells as a result of an imbalance between oxidants and antioxidants.
Jinthe Van Loenhout, Marc Peeters, Annemie Bogaerts, Evelien Smits, Christophe Deben   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Research on lightweight 5GC application in emergency communication

Dianzi Jishu Yingyong, 2020
Emergency communication support requires rapid deployment, quick on-line and simplified configuration process, but the network architecture based on 3GPP standard is too large and complex to meet.
Zhu Xuetian, Wang Qiuhong, Zhang Shaowei, Hou Jijiang   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

DRP1 depletion protects NK cells from hypoxia-induced dysfunction

Redox Report
Objectives The efficacy of cellular therapies has been disappointing in solid tumors. A major barrier that contributes to the low success rate, is hypoxia within the tumor microenvironment.
Tias Verhezen, Astrid Van Den Eynde, Peter Verstraelen, Laura Gehrcken, Gabriele Palmiotto, Ho Wa Lau, Winnok H. De Vos, Sanne Van Der Heijden, Louize Brants, Jöran Melis, Jonas Van Audenaerde, Felicia Rodrigues Fortes, Maxim Le Compte, Geert Roeyen, Hans Prenen, Diana Campillo-Davo, Eva Lion, Rafael J. Argüello, Steven Van Laere, Filip Lardon, Christophe Deben, An Wouters, Evelien Smits, Jorrit De Waele   +23 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source