Molecular mechanisms and functions of cell death induced by corilagin in human breast cancer cells [PDF]
, 2017 乳腺癌是最常见的恶性肿瘤之一，严重危害女性健康。近几十年来，尽管治疗效果取得了长足的进步，但发展中国家乳腺癌的发病率仍在大幅上升。因此，开发新的药物治疗乳腺癌显得十分重要。柯里拉京(Corilagin)是一种天然多酚类物质。研究表明，柯里拉京具有抗肿瘤、抗痛觉过敏、抗病毒、治疗心血管疾病等多种生物活性，且不良反应低，近年来受到研究者的广泛关注，但其在乳腺癌中的生物学作用和潜在机制却鲜有报道。程序性细胞死亡主要包括凋亡、自噬和程序性坏死。凋亡是程序性死亡的普遍途径；自噬是调控细胞存活的方式 ...
童银萍
core
Corilagin alleviates ferroptosis in diabetic retinopathy by activating the Nrf2 signaling pathway
Biomedicine & PharmacotherapyDiabetic retinopathy (DR) is a prevalent complication of diabetes, with a rising global incidence, and can result in significant vision impairment and potential blindness in adults. Corilagin (COR) has been shown to regulate several pathological processes.
Wenxin, Shi +4 more
openaire +2 more sources
Frontiers in PharmacologyWomen have been found to be at a higher risk of morbidity and mortality from type 2 diabetes mellitus (T2DM) and asthma. α-Glucosidase inhibitors have been used to treat T2DM, and arachidonic acid 15-lipoxygenase (ALOX15) inhibitors have been suggested ...
Mavis Colleen Porciuncula Fabian +4 more
doaj +1 more source
Unraveling phytochemicals with potential therapeutic application for neurodegeneration [PDF]
, 2017 "Epidemiological data suggest that phytochemicals may prevent and even reverse specific pathological processes underlying neurodegenerative diseases. A (poly)phenol-enriched fraction from leaves of Corema album was previously reported to modulate central
Vaz, Marcela Tatiana Barros
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Synthesis of Silver and Gold Nanoparticles through Reduction Method using Bioreductor of Leaf Extract of Ketapang (Terminalia catappa) [PDF]
-Synthesis of silver and gold nano-particles was carried out by the reduction method with leaf extract of Ketapang (Terminalia catappa). The biomolecules present in the extract generated the reduction of Ag+ and Au3+ ions from AgNO3 and HAuCl4 ...
Gaffar, Maming +3 more
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Corilagin Alleviates Ang II-Induced Cardiac Fibrosis by Regulating the PTEN/AKT/mTOR Pathway
Dose-ResponseThis research aimed to evaluate the therapeutic effect of corilagin (Cor) against angiotensin II (Ang II)-induced cardiac fibrosis and its underlying mechanisms.
Xiaogang Zhang +3 more
doaj +1 more source
Polyphenols contribute to the antioxidant and antiproliferative activity of Phyllanthus debilis plant in-vitro [PDF]
, 2016 Dananjaya Perera +2 more
core +1 more source
Study on the astringent mechanism of <i>Chebulae fructus</i>. [PDF]
Food Chem XZheng Y +10 more
europepmc +1 more source
Longan Flower Ethanol Extract, <i>Dimocarpus longan</i> Lour, Mitigates Oxidative Damage and Inflammatory Responses While Promoting Sleep-Related Enzymes in Cell Models. [PDF]
BiomedicinesMa CC +9 more
europepmc +1 more source
Integration of Network Pharmacology, Molecular Docking, and In Vitro Nitric Oxide Inhibition Assay to Explore the Mechanism of Action of Thai Traditional Polyherbal Remedy, Mo-Ha-Rak, in the Treatment of Prolonged Fever. [PDF]
Pharmaceuticals (Basel)Chaloemram C +3 more
europepmc +1 more source