Results 61 to 70 of about 182,932 (248)

Zebrafish cornea formation and homeostasis reveal a slow maturation process, similarly to terrestrial vertebrates’ corneas

Frontiers in Physiology, 2022
Corneal blindness is the fourth leading cause of blindness worldwide. The superficial position of cornea on the eye makes this tissue prone to environmental aggressions, which can have a strong impact on sight.
Kaisa Ikkala, Sini Raatikainen, Henri Koivula, Frederic Michon, Frederic Michon   +4 more
doaj   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Trachomatous trichiasis and its management in endemic countries. [PDF]

, 2012
: Trichiasis is the sight-threatening consequence of conjunctival scarring in trachoma, the most common infectious cause of blindness worldwide. Trachomatous trichiasis is the result of multiple infections from childhood with Chlamydia trachomatis, which
Saul N. Rajak, Rajak, SN, Matthew J. Burton, Collin, J Richard O, Collin, JR, Burton, Matthew J, J. Richard O. Collin, Burton, MJ, Rajak, Saul N   +8 more
core   +1 more source

Indications and Outcomes of Corneal Transplant Surgery in Ghana [PDF]

, 2021
Background: Corneal blindness contributes to 25% of all blindness. We review corneal transplant, a common surgical remedy, in Ghana to determine indications and visual outcomes in resource-poor environments. Methods: A retrospective cross-sectional study
Emmanuel Owusu Poku, Poku, Emmanuel Owusu, Seth Lartey, Lartey, Seth, Mohammed, Abdul Kabir, Antwi-Adjei, Ellen Konadu, Ellen Konadu Antwi-Adjei, Abdul Kabir Mohammed   +7 more
core   +1 more source

A new vision through combined osteo-odonto-keratoplasty: A review

Medical Journal of Dr. D.Y. Patil University, 2014
This is an extensive review of osteo-odonto-keratoplasty (OOKP) where the vision is restored by using tooth as an implant in the environment of the eye. The window of the soul is our eye and the window of the eye is cornea.
Lakshmi Shetty, Archana Gupta, Nidhi Shah, Umang Shah   +3 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Ecological determinants of blindness in Nigeria: the Nigeria National Blindness and Visual Impairment Survey. [PDF]

, 2011
OBJECTIVE: To determine the prevalence and causes of visual loss in different ecological zones across Nigeria. METHODS: A population-based survey using multi-stage, stratified, cluster random sampling with probability proportional to size comprising a ...
Abubakar, Tafida, Rabiu, MM, Kyari, Fatima, Nigeria National Blindness and Visual Impairment Study Group, Gudlavalleti, Murthy VS, Gilbert, CE, Sivasubramaniam, Selvaraj, Gudlavalleti, Murthy V S, Gilbert, C E, Rabiu, M M   +9 more
core   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Pattern of Corneal Disorders at a Tertiary Care Centre in Amritsar, Punjab, India: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Corneal disease is the fifth leading cause of blindness in the world. The burden of corneal blindness is higher in developing countries like India, where corneal opacity contributes to 8.2% of the blind population.
Brijesh Singla, Anubha Bhatti, Manveen Kukreja, Saroj Bala, Karamjit Singh, Sonam Juneja   +5 more
doaj   +1 more source

Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants

Molecular Therapy: Nucleic Acids, 2022
Herpes simplex virus (HSV) infection is a leading cause of corneal blindness. However, keratoplasty is only rarely proposed due to the high frequency of graft failure and associated recurrences.
Benoit Chapellier, Damien Guindolet, Daniel Pereira, Roman Galetto, José-Alain Sahel, Marc Labetoulle, Eric E. Gabison   +6 more
doaj   +1 more source