Results 81 to 90 of about 182,932 (248)

Pattern of ocular morbidity among students in a school for visually impaired children in North India

Oman Journal of Ophthalmology, 2020
AIMS: The aim of this study was to identify the ocular morbidity pattern among children attending a blind school in North India and comparing the data with similar studies conducted across India and abroad.
Shaik Mohammed Zakir, Md Shahid Alam, Saiyid Nasir Askari, Mohd Imran   +3 more
doaj   +1 more source

Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer, Britt‐Marie Anderlid, Lena Jacobson, Daniel Martín Muñoz, Erik Björck   +4 more
wiley   +1 more source

Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial. [PDF]

, 2011
Trachomatous trichiasis can cause corneal damage and visual impairment. WHO recommends surgery for all cases. However, in many regions surgical provision is inadequate and patients frequently decline.
Saul N. Rajak, Habtamu, E, Amir Bedri Kello, Helen A Weiss, Emerson Paul M., Peng T. Khaw, Weiss Helen A., Rajak, SN, Gebre Teshome, Burton Matthew J., Helen A. Weiss, Gebre, Teshome, Robin L Bailey, Paul M Emerson, Matthew J. Burton, Gilbert, CE, Clare E Gilbert, Matthew J Burton, Khaw Peng T., Rajak Saul N., Habtamu Esmael, Saul N Rajak, David C. W. Mabey, Emerson, PM, Weiss, Helen A, Kello, AB, Genet, A, Khaw, PT, Genet Asrat, Bailey Robin L., Gebre, T, Bailey, RL, Gilbert Clare E., David C W Mabey, Clare E. Gilbert, Rajak, Saul N, Habtamu, Esmael, Kello Amir Bedri, Teshome Gebre, Weiss, HA, Peng T Khaw, Burton, Matthew J, Esmael Habtamu, Mabey David C. W., Genet, Asrat, Kello, Amir Bedri, Gilbert, Clare E, Emerson, Paul M, Bailey, Robin L, Khaw, Peng T, Asrat Genet, Mabey, DC, Paul M. Emerson, Mabey, David CW, Burton, MJ, Robin L. Bailey   +55 more
core   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Visual prosthesis for corneal blindness

, 2019
Objective: Corneal opacity is a leading cause of reversible blindness worldwide. Current treatments such as corneal transplantation and keratoprosthesis have fundamental limitations (i.e. 13 million remain on corneal transplant waitlists). An electronic display based corneal visual prosthesis placed[for full text, please go to the a.m. URL]
Yu, C, Fan, V, Vieira, I
openaire   +2 more sources

A self‐retaining mouth prop for intraoral access during periodontal surgery in rat models: A technical note

Animal Models and Experimental Medicine, EarlyView.
A mouth prop designed to mimic the oral cavity of rats was made that provided stable, self‐retaining retraction, thereby facilitating oral surgery on rodents. Compared to conventional methods, it decreased surgical time, operator fatigue, and slippage. Its use led to higher efficiency and fewer complications and it was cost effective to produce.
Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Vivek Kumar Thakur, Balaji Manohar, Shaili Pradhan, Shesh Rai   +5 more
wiley   +1 more source

Demographic characteristics and the prevalence of corneal blindness.

, 2014
aComparisons between males and females. Blindness in both eyes, χ2 = 2.18, p = 0.14; blindness in one eye, χ2 = 3.48, p = 0.06; blindness in at least one eye(total), χ2 = 5.25, p = 0.02 (statistically significant difference).bComparisons between ...
Lixin Xie (41999), Xiusheng Song (667612), Qing Wang (27728), Yingping Deng (667615), Yanning Yang (667614), Jianjiang Xu (647147), Xiaodong Tan (667613), Xunlun Sheng (564726), Zhichong Wang (196668), Shaoying Fu (667616), Yuansheng Yuan (399635), Xuguang Sun (667617)   +11 more
core   +1 more source

The Multiple Criteria Qualitative Value‐Based Pricing Framework “MARIE” for Novel Cell and Gene Therapy

Clinical Pharmacology &Therapeutics, EarlyView.
When setting the price of cell and gene therapies in Japan, the factors considered include the manufacturing and operating costs of the new drug or a comparator, leading to discrepancies between price and values, in particular those specific to cell and gene therapies.
Akina Takami, Ataru Igarashi
wiley   +1 more source

Clinical Applications of Corneal Cells Derived from Induced Pluripotent Stem Cells

Biomolecules
Corneal diseases are among the leading causes of blindness worldwide and the standard treatment is the transplantation of corneal donor tissue. Treatment for cornea-related visual impairment and blindness is, however, often constrained by the global ...
Yixin Luan, Aytan Musayeva, Jina Kim, Debbie Le Blon, Bert van den Bogerd, Mor M. Dickman, Vanessa L. S. LaPointe, Sorcha Ni Dhubhghaill, Silke Oellerich   +8 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source