Results 71 to 80 of about 182,932 (248)

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Differentiation of Human Mesenchymal Stem Cells into Corneal Epithelial Cells: Current Progress

Current Issues in Molecular Biology
The limited availability of corneal tissue grafts poses significant challenges in the treatment of corneal blindness. Novel treatment utilizes stem cell grafts transplanted from the healthy side of the cornea to the damaged side.
Abdul Malik Setiawan, Taty Anna Kamarudin   +1 more
doaj   +1 more source

Nanomedicine Approaches for Corneal Diseases

Journal of Functional Biomaterials, 2015
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions.
Shyam S. Chaurasia, Rayne R. Lim, Rajamani Lakshminarayanan, Rajiv R. Mohan   +3 more
doaj   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Molecular and Cellular Mechanisms of Corneal Scarring and Advances in Therapy

, 2023
On the basis of WHO global blindness data, it may be stated that 23 million people globally suffer from unilateral corneal blindness, while 4 [...
Vishal Jhanji, Matthias Fuest, Gary Hin-Fai Yam   +2 more
core   +1 more source

AI‐Powered Smart Displays and AR Glasses: Perspectives and Challenges

Advanced Intelligent Systems, EarlyView.
This perspective examines how AI is reshaping smart displays and AR glasses. The latest in image‐quality enhancement, sensor‐integrated display optimization, and physiological sensing in display systems, followed by AI‐assisted AR technologies including waveguide optimization, image compensation, foveated rendering, and multimodal sensing, is discussed.
Luke Benoit, Yizhou Qian, Yi‐Chien Chen, Ziyang Shen, Po‐Sheng Chiu, Youngeon Lee, Cheng‐Han Ke, Chih‐Lung Lin, Shin‐Tson Wu   +8 more
wiley   +1 more source

Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]

, 1999
Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Mickler, A., Klauss, V., Krumpaszky, H. G., Lüdtke, R., Selbmann, H. K.   +4 more
core   +1 more source

Outcome of penetrating keratoplasty in patients with bilateral corneal blindness [PDF]

Eye, 2004
To evaluate the outcome of penetrating keratoplasty in patients with bilateral corneal blindness.Bilaterally blind patients who had undergone optical penetrating keratoplasty (PK) were evaluated on optical and refractive parameters and presence of complications if any.
R, Sinha, M, Vanathi, N, Sharma, J S, Titiyal, R B, Vajpayee, R, Tandon   +5 more
openaire   +2 more sources

Potential of hospital corneal retrieval program in tertiary care center

Journal of Clinical Ophthalmology and Research
Context: In developing nations, corneal diseases are the second leading cause of blindness. Despite the effectiveness of corneal transplantation, India struggles with a substantial corneal blind population and inadequate access to quality donor corneal ...
Ujwala Weladi, Snehal Bonde Chaurasia
doaj   +1 more source