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Corneal Endothelial Dysfunction: Evolving Understanding and Treatment Options
The cornea is exquisitely designed to protect the eye while transmitting and focusing incoming light. Precise control of corneal hydration by the endothelial cell layer that lines the inner surface of the cornea is required for optimal transparency, and endothelial dysfunction or damage can result in corneal edema and visual impairment.
Jodhbir S Mehta +2 more
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Corneal Endothelial Dysfunction as a Manifestation of Digoxin Toxicity
Cornea, 2022Purpose: The purpose of this study was to report a case of corneal endothelial dysfunction and subsequent corneal edema in a patient with digoxin toxicity. Method: This was a case report.
Angi Lizbeth, Mendoza-Moreira +5 more
openaire +2 more sources
The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction
Current Pharmaceutical Design, 2017The cornea is transparent tissue that serves as the window of the eye, allowing light to enter from the outer environment. The corneal endothelium maintains corneal transparency; thus, its dysfunction results in corneal haziness and causes severe vision loss.
Shigeru Kinoshita +2 more
exaly +3 more sources
Hyperglycemia Induces Corneal Endothelial Dysfunction Through Attenuating Mitophagy
Experimental Eye Research, 2022Hyperglycemia increases the risk of corneal endothelial dysfunction, resulting in damage to corneal endothelial structure and function. However, the effect and mechanism of hyperglycemia-induced corneal endothelial damage remain elusive. In this study, we demonstrated that hyperglycemia reduced the expression of pump-related protein Na+/K+ ATPase and ...
Lixin Xie, Huifeng Wang
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Corneal endothelial dysfunction in Pearson syndrome
Ophthalmic Genetics, 2011Mitochondrial disorders are associated with well recognized ocular manifestations. Pearson syndrome is an often fatal, multisystem, mitochondrial disorder that causes variable bone marrow, hepatic, renal and pancreatic exocrine dysfunction. Phenotypic progression of ocular disease in a 12-year-old male with Pearson syndrome is described.
Shivani A, Kasbekar +4 more
openaire +3 more sources
Advances in Therapy, 2020
A recent successful clinical trial demonstrated that a less invasive cell-injection procedure is a viable medical modality for treating corneal endothelial dystrophy. This medical advance still relies on human corneal endothelial cell (HCEC) sources derived from rare cornea donations.
Yaa-Jyuhn J. Meir +3 more
openaire +2 more sources
A recent successful clinical trial demonstrated that a less invasive cell-injection procedure is a viable medical modality for treating corneal endothelial dystrophy. This medical advance still relies on human corneal endothelial cell (HCEC) sources derived from rare cornea donations.
Yaa-Jyuhn J. Meir +3 more
openaire +2 more sources
Corneal Endothelial Dysfunction Associated With Amantadine Toxicity
Cornea, 2008To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.We employed an A-B-A-B single-subject research design that included clinical history, clinical findings, photographic images, and specular microscopic findings of ocular changes.A 52-year-old woman with Parkinson disease ...
Ki Cheol, Chang +3 more
openaire +2 more sources
Cornea, 2014
Corneal endotheliitis causes endothelial decompensation and is associated with significant visual impairment. The goal of this article is to report a case of corneal endotheliitis associated with coxsackievirus A24 infection after cataract surgery in a patient who had no previous symptoms indicative of conjunctivitis.A 55-year-old man was admitted for ...
Dong Hui, Lim +4 more
openaire +2 more sources
Corneal endotheliitis causes endothelial decompensation and is associated with significant visual impairment. The goal of this article is to report a case of corneal endotheliitis associated with coxsackievirus A24 infection after cataract surgery in a patient who had no previous symptoms indicative of conjunctivitis.A 55-year-old man was admitted for ...
Dong Hui, Lim +4 more
openaire +2 more sources
Current Eye Research, 2017
To evaluate the effect of transplanting bioengineered corneal endothelial grafts in a rabbit model of corneal endothelial failure.Human corneal endothelial cells (HCECs) were seeded on a vitrigel carrier. After Descemet's membrane was removed from the eyes of rabbits, transplantation was done with a vitrigel/HCEC graft or vitrigel alone without cells ...
Junko Yoshida +2 more
exaly +3 more sources
To evaluate the effect of transplanting bioengineered corneal endothelial grafts in a rabbit model of corneal endothelial failure.Human corneal endothelial cells (HCECs) were seeded on a vitrigel carrier. After Descemet's membrane was removed from the eyes of rabbits, transplantation was done with a vitrigel/HCEC graft or vitrigel alone without cells ...
Junko Yoshida +2 more
exaly +3 more sources

