Results 171 to 180 of about 959,050 (193)
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Cell-Based Approach for Treatment of Corneal Endothelial Dysfunction
Cornea, 2014Decompensation of the corneal endothelium causes severe visual impairments that lead to blindness. Although corneal transplantation is a well-known effective therapy for corneal endothelial dysfunction, many patients are not afforded that therapeutic opportunity owing to the worldwide shortage of donor corneas.
Naoki, Okumura +2 more
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Acta Biomaterialia
Considering the limitations of human corneal endothelial cell proliferation as well as the severe shortage of corneal donations, it is imperative to develop improved methods of corneal endothelial cell transplantation. The purpose of this study was to construct a modified corneal endothelial cell transplantation approach using thermosensitive hydrogels
Baoqin Han, Ruibao Ju, Jinhua Chi
exaly +3 more sources
Considering the limitations of human corneal endothelial cell proliferation as well as the severe shortage of corneal donations, it is imperative to develop improved methods of corneal endothelial cell transplantation. The purpose of this study was to construct a modified corneal endothelial cell transplantation approach using thermosensitive hydrogels
Baoqin Han, Ruibao Ju, Jinhua Chi
exaly +3 more sources
European Journal of Ophthalmology, 2022
Purpose To evaluate the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) performed in eyes with comorbid keratoconus (KCN) and corneal endothelial dysfunction. Methods Twenty-five consecutive eyes of 14 patients ...
Philip W. Dockery +6 more
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Purpose To evaluate the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) performed in eyes with comorbid keratoconus (KCN) and corneal endothelial dysfunction. Methods Twenty-five consecutive eyes of 14 patients ...
Philip W. Dockery +6 more
openaire +2 more sources
Cornea, 2014
To evaluate clinical outcomes and complications after Descemet membrane endothelial keratoplasty (DMEK) in a child.A 12-year-old boy with Kearns-Sayre syndrome (chronic progressive external ophthalmoplegia, cardiac conduction block, and pigmentary retinal degeneration) and corneal endothelial dysfunction was successfully treated with DMEK.
Johannes, Gonnermann +7 more
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To evaluate clinical outcomes and complications after Descemet membrane endothelial keratoplasty (DMEK) in a child.A 12-year-old boy with Kearns-Sayre syndrome (chronic progressive external ophthalmoplegia, cardiac conduction block, and pigmentary retinal degeneration) and corneal endothelial dysfunction was successfully treated with DMEK.
Johannes, Gonnermann +7 more
openaire +2 more sources
Emerging alternatives to keratoplasty for corneal endothelial cell dysfunction
Current Opinion in OphthalmologyPurpose of review While effective for treating endothelial dysfunction, keratoplasty has shortcomings including limited access to donor tissue for much of the world. Thus, alternative strategies are under development. This review explores the main advancements achieved in this field during 2022–2023.
Ron, Kaufman, Albert S, Jun
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Targeting the NRF2 Pathway: A Promising Approach for Corneal Endothelial Dysfunction
Current Opinion in PharmacologyMaintaining corneal endothelial function is required for vision, and corneal endothelial dysfunction is a major cause of visual deficits and blindness worldwide. To date there has been a dearth of innovation for therapeutics targeting the corneal endothelium.
exaly +3 more sources
Memantine-Associated Corneal Endothelial Dysfunction
JAMA Ophthalmology, 2015Matthew T, Feng +3 more
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Experimental Eye Research
Diabetic mellitus (DM) causes various complications, including the corneal endothelial dysfunction that leads to corneal edema and vision loss, especially in the DM patients with intraocular surgeries. However, the pathogenic mechanism of hyperglycemia-caused corneal endothelial dysfunction remains incomplete understood.
Mengmeng Yu +6 more
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Diabetic mellitus (DM) causes various complications, including the corneal endothelial dysfunction that leads to corneal edema and vision loss, especially in the DM patients with intraocular surgeries. However, the pathogenic mechanism of hyperglycemia-caused corneal endothelial dysfunction remains incomplete understood.
Mengmeng Yu +6 more
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Advanced Diagnosis of Corneal Endothelial Dysfunction
O endotélio corneano desempenha um papel essencial na preservação da transparência da córnea, assegurando a homeostase do fluido estromal através de complexos juncionais e da actividade da bomba Na⁺/K⁺-ATPase. Dada a sua natureza não regenerativa, a perda celular progressiva — decorrente do envelhecimento, de traumas ou de patologias hereditárias como ...Vaz, Mariana Domingues +7 more
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