Results 1 to 10 of about 315,440 (342)
Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium [PDF]
Advanced Science, 2022 Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its ...
Eleonora Maurizi +7 more
doaj +3 more sources
The Multifarious Effects of Various Glaucoma Pharmacotherapy on Corneal Endothelium: A Narrative Review [PDF]
Ophthalmology and Therapy, 2023 Corneal endothelium is a single cell layer that is mainly responsible for maintaining corneal clarity. Endothelial damage secondary to toxicity, stress, or genetic predisposition are common and in conjunction with the low regenerative ability of the ...
Stylianos A. Kandarakis +6 more
doaj +4 more sources
Diseases of the corneal endothelium. [PDF]
Exp Eye Res, 2021 The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is a unique structure that plays an essential role in corneal function. Endothelial cells are neural crest derived cells that rest on a special extracellular matrix and play a major role in maintaining stromal hydration within a narrow physiologic range necessary for ...
Jeang LJ, Margo CE, Espana EM.
europepmc +4 more sources
Mesothelial cells: A cellular surrogate for tissue engineering of corneal endothelium [PDF]
Investigative Ophthalmology and Visual Science, 2015 [Purpose]: To evaluate whether mouse adipose tissue mesothelial cells (ATMCs) share morphologic and biochemical characteristics with mouse corneal endothelial cells (CECs) and to evaluate their capacity to adhere to the decellularized basal membrane of ...
Alió, Jorge +6 more
core +4 more sources
Cells, 2019 The corneal endothelium regulates corneal hydration to maintain the transparency of cornea. Lacking regenerative capacity, corneal endothelial cell loss due to aging and diseases can lead to corneal edema and vision loss.
Gary Hin-Fai Yam +8 more
doaj +4 more sources
PLoS ONE, 2021 Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD).
Eric D Wieben +7 more
doaj +2 more sources
The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness [PDF]
Scientific Reports, 2021 Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage.
Yoo Jin Kim, Tae Gi Kim
openalex +2 more sources
Research Progress of Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering [PDF]
Nanomaterials, 2023 Nowadays, treating corneal diseases arising from injury to the corneal endothelium necessitates donor tissue, but these corneas are extremely scarce. As a result, researchers are dedicating significant efforts to exploring alternative approaches that do ...
Xiaoying Luo +8 more
doaj +2 more sources
Corneal endothelial regeneration in human eyes using endothelium-free grafts [PDF]
BMC Ophthalmology, 2022 Background To report on corneal endothelial regeneration, graft clarity, and vision recovery when using endothelium-free grafts. Methods We evaluated the donor’s cell viability using trypan blue staining and dual staining with calcein acetoxy methyl ...
Lu-Yi Ying +5 more
doaj +2 more sources
Spatiotemporal gene targeting in the mouse corneal endothelium [PDF]
Taiwan Journal of Ophthalmology, 2023 PURPOSE: The inducible Cre-ERT2 recombinase system allows for temporal control of gene targeting, and it is useful to studying adult function of genes that have critical developmental roles.
JeongGoo Lee, Martin Heur
doaj +2 more sources